{
  "abstract": "Introduction: Clinical data surrounding treatment patterns and reasons for discontinuation of oral systemics (OS) for the treatment of adult patients with moderate-severe atopic dermatitis (AD) remain limited. AD-REAL descriptively reports the discontinuation rates and treatment responses at week (W) 24 for patients with AD initiating new OS treatments. Methods: AD-REAL is a 12-month, multinational, observational cohort study of adult patients with moderate-to-severe AD commencing either conventional systemics (CS) or baricitinib. Other Janus kinase inhibitors (JAKis) were analyzed ad hoc. The primary objective reported the discontinuation rate of patients at W24 from baseline. Secondary objectives reported outcomes for Eczema Area and Severity index",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Matthias Augustin"
    },
    {
      "name": "Andreas Pinter"
    },
    {
      "name": "Silvia Sabatino"
    },
    {
      "name": "Louis P Sanden"
    },
    {
      "name": "Pablo Chicharro"
    },
    {
      "name": "Esther Serra-Baldrich"
    },
    {
      "name": "Mahreen Ameen"
    },
    {
      "name": "Anthony Bewley"
    },
    {
      "name": "Walid Fakhouri"
    },
    {
      "name": "Inmaculada de la Torre"
    },
    {
      "name": "Julien Seneschal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ermf27xm1gxqc.bib",
  "cited_by": 0,
  "doi": "10.1007/s13555-026-01852-5",
  "fulltext_url": null,
  "id": "ermf27xm1gxqc",
  "issns": [
    "2193-8210",
    "2193-8210"
  ],
  "landing_url": "https://u-bordeaux.hal.science/hal-05743608v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.imm"
    ],
    [
      "openalex",
      "2708|Dermatology and Skin Diseases"
    ]
  ],
  "openalex": "W7171868475",
  "pdf_url": "https://u-bordeaux.hal.science/hal-05743608/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ermf27xm1gxqc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "hal-05743608",
      "source": "hal",
      "url": "https://u-bordeaux.hal.science/hal-05743608v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    }
  ],
  "title": "AD-REAL: A Prospective, Multinational, Observational Cohort Study of Clinical Effectiveness and Treatment Discontinuation of Oral Systemics for Moderate-to-Severe Atopic Dermatitis",
  "title_text": "AD-REAL: A Prospective, Multinational, Observational Cohort Study of Clinical Effectiveness and Treatment Discontinuation of Oral Systemics for Moderate-to-Severe Atopic Dermatitis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/ermf27xm1gxqc",
  "venue": "Dermatology and Therapy",
  "versions": []
}