{
  "abstract": "Copper is an essential cofactor for numerous metabolic pathways; however, excess intracellular copper is cytotoxic. In this study, we investigated the consequences of deregulated Cu+ uptake mediated by the high-affinity copper transporter Ctr1 in the model yeast Saccharomyces cerevisiae. Constitutive expression of a carboxy-terminally truncated Ctr1 variant, CTR1(300), resulted in elevated intracellular copper levels, increased oxidative stress, and reduced oxygen consumption, likely due to impairment of iron-sulfur cluster-containing proteins. Notably, CTR1(300)-expressing cells exhibited a pronounced repression of global protein synthesis at very low copper concentrations, a phenotype that was recapitulated in wild-type cells when exposed to higher copper levels. These findings reveal that excessive Cu+ accumulation negatively impacts cellular respiration and translation, identifying protein synthesis as a sensitive target of copper toxicity.",
  "abstract_shown": true,
  "affiliations": [
    "Departament de Bioquímica i Biología Molecular, Universitat de València",
    "Departamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC)"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Amparo Andrés-Bordería"
    },
    {
      "affs": [
        1
      ],
      "name": "Antonia M. Romero"
    },
    {
      "affs": [
        1
      ],
      "name": "Raquel Sorribes-Dauden"
    },
    {
      "affs": [
        0
      ],
      "name": "Lola Peñarrubia"
    },
    {
      "affs": [
        0
      ],
      "name": "María T. Martínez-Pastor"
    },
    {
      "affs": [
        1
      ],
      "name": "Sergi Puig"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana Perea-García"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/erqej2sp9t6wk.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-56882-y",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-56882-y",
  "id": "erqej2sp9t6wk",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-56882-y",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2916|Trace Elements in Health"
    ]
  ],
  "openalex": "W7164191947",
  "pdf_url": "https://www.nature.com/articles/s41598-026-56882-y_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/erqej2sp9t6wk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:42Z",
      "native_id": "2baf80f7c5a346c19f1d8ab9ca0bc065",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-56882-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:R",
      "subfield": "general"
    }
  ],
  "title": "Excess copper causes repression of global translation in Saccharomyces cerevisiae",
  "title_text": "Excess copper causes repression of global translation in Saccharomyces cerevisiae",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:42Z",
  "url": "https://research.draconitic.com/paper/erqej2sp9t6wk",
  "venue": "Scientific Reports",
  "versions": []
}