{
  "abstract": "Recently, the pentafluorosulfanyl (SF₅) group has attracted considerable interest from medicinal chemists owing to its capacity to significantly enhance the pharmaceutical properties of small-molecule drug candidates. However, a general method for three-component pentafluorosulfanylation of electron-deficient alkenes remains elusive. Herein, we present an electron donor-acceptor (EDA) complex photoactivation strategy for the thiopentafluorosulfanylation of unsaturated hydrocarbons, including electron-deficient alkenes, alkynes, 1,6-enynes, and even acetylene gas. The utility of this approach is demonstrated through the synthesis of a diverse array of pentafluorosulfanyl thioethers and the late-stage functionalization of complex molecules, including pharmaceuticals, natural products, and amino acid derivatives. This work establishes a framework for designing atom-economical difunctionalization reactions that employ green LEDs under mild conditions. Moreover, mechanistic studies support an EDA complex-mediated pathway and identify ArSCl as a key intermediate formed upon generation of the thiyl radical.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Green Chemistry and Environment, College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P. R. China.",
    "Sichuan Tourism University, Chengdu, 610100, P. R. China.",
    "Molecular Toxicology Key Laboratory of Sichuan Provincial Education Office, Department of Hygienic Toxicology and Pathology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, China.",
    "Institute of Green Chemistry and Environment, College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P. R. China. yueshuai922@imu.edu.cn.",
    "Institute of Green Chemistry and Environment, College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P. R. China. shuoguo@imu.edu.cn.",
    "Institute of Green Chemistry and Environment, College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P. R. China. wangjb@imu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaofeng Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuanyang Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui-Yi Yang",
      "orcid": "0000-0002-6687-3694"
    },
    {
      "affs": [
        0
      ],
      "name": "Yifan Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiangshan Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ning Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Gang Wu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Donglei Sun"
    },
    {
      "affs": [
        2
      ],
      "name": "Yi Shi"
    },
    {
      "affs": [
        2
      ],
      "name": "Wei Zhang",
      "orcid": "0000-0003-3765-4908"
    },
    {
      "affs": [
        3
      ],
      "name": "Shuaishuai Yue",
      "orcid": "0009-0007-3730-5448"
    },
    {
      "affs": [
        4
      ],
      "name": "Shuo Guo",
      "orcid": "0000-0002-3042-9209"
    },
    {
      "affs": [
        5
      ],
      "name": "Jianbo Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/es025j52d3hts.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77739-y",
  "fulltext_url": "https://europepmc.org/articles/PMC13669357",
  "id": "es025j52d3hts",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42875439",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7213199842",
  "pdf_url": "https://europepmc.org/articles/PMC13669357?pdf=render",
  "pmcid": "PMC13669357",
  "pmid": "42875439",
  "published": "2026-09-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/es025j52d3hts.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:18Z",
      "native_id": "MED:42875439",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42875439"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Difunctionalization of unsaturated hydrocarbons via EDA complexes to access pentafluorosulfanyl thioethers.",
  "title_text": "Difunctionalization of unsaturated hydrocarbons via EDA complexes to access pentafluorosulfanyl thioethers.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:18Z",
  "url": "https://research.draconitic.com/paper/es025j52d3hts",
  "venue": "Nature communications",
  "versions": []
}