{
  "abstract": "Platelet-Released Growth Factors (PRGF) are a standardized, cell- and fibrin-free platelet lysate with translational potential for tissue repair. PRGF enhance tissue regeneration, particularly in contexts where angiogenesis is critical for restoring perfusion in chronic and non-healing wounds. Here, we present the first in vitro study demonstrating that PRGF exert pro-angiogenic effects at a working concentration of 10%. The study employs an endothelial cell-based model integrating targeted gene expression analysis, array-based profiling of angiogenesis-related proteins, and functional endothelial tube formation assays. In this setting, screening-level transcriptional and proteomic profiling indicated higher transcript levels of angiogenesis-related genes and increased signals of representative angiogenesis-associated mediators (e.g., Platelet Factor 4, Angiopoietin-1, Angiogenin) following PRGF stimulation. Functional tube formation assays demonstrated significant enhancement of multiple pro-angiogenic parameters in response to PRGF, including number of pieces (P < 0.001), junctions (P < 0.01), and segments (P < 0.05). These findings suggest that 10% PRGF may support angiogenesis and tissue regeneration and provide a foundation for further validation in more complex multicellular systems and in vivo models.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Michael Singh"
    },
    {
      "name": "Karina Zitta"
    },
    {
      "name": "Thilo Wedel"
    },
    {
      "name": "Ralph Lucius"
    },
    {
      "name": "François Cossais"
    },
    {
      "name": "Peter Behrendt"
    },
    {
      "name": "Sabine Fuchs"
    },
    {
      "name": "Jan-Tobias Weitkamp"
    },
    {
      "name": "Rouven Berndt"
    },
    {
      "name": "Olga Zimmermann"
    },
    {
      "name": "Tim Schricker"
    },
    {
      "name": "Andreas Bayer"
    },
    {
      "name": "Martin Albrecht"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/es3e8csv9ssh8.bib",
  "cited_by": 1,
  "doi": "10.1186/s13287-026-05214-y",
  "fulltext_url": null,
  "id": "es3e8csv9ssh8",
  "issns": [
    "1574-888X",
    "2212-3946"
  ],
  "landing_url": "https://normandie-univ.hal.science/hal-05771356v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2748|Periodontal Regeneration and Treatments"
    ]
  ],
  "openalex": "W7172500481",
  "pdf_url": "https://link.springer.com/content/pdf/10.1186/s13287-026-05214-y.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-05",
  "publisher": "Bentham Science Publishers Ltd",
  "ris": "https://research.draconitic.com/paper/es3e8csv9ssh8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:44Z",
      "native_id": "hal-05771356",
      "source": "hal",
      "url": "https://normandie-univ.hal.science/hal-05771356v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Platelet-released growth factors promote pro-angiogenic effects in endothelial cells: a translational perspective on wound healing and regenerative medicine",
  "title_text": "Platelet-released growth factors promote pro-angiogenic effects in endothelial cells: a translational perspective on wound healing and regenerative medicine",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:44Z",
  "url": "https://research.draconitic.com/paper/es3e8csv9ssh8",
  "venue": "Current Stem Cell Research & Therapy",
  "versions": []
}