{
  "abstract": "Nasopharyngeal carcinoma (NPC) exhibits significant geographical clustering and etiological heterogeneity. It is particularly prevalent in Southeast Asia and is typically associated with Epstein-Barr virus (EBV) infection. Reactive oxygen species (ROS), as highly reactive oxygen metabolites, play a key role in regulating cellular signaling and maintaining redox homeostasis. Although the role of ROS in tumors has been well established, reviews examining how ROS influence NPC and their potential therapeutic applications remain relatively scarce. ROS exert diverse effects in NPC, including roles in EBV-associated processes, regulation of programmed cell death, metabolic reprogramming, formation of an immunosuppressive tumor microenvironment, and epigenetic remodeling. In addition, natural small-molecule compounds that regulate ROS levels and emerging combination therapy strategies have considerable therapeutic potential in NPC. This review discusses the dual role of ROS in NPC, examines their contributions to disease development, and further explores how these mechanisms could inform the design of ROS-targeted therapies, as well as the associated translational challenges.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Yangtze University, The First People’s Hospital of Jingzhou"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuting Gu"
    },
    {
      "affs": [
        0
      ],
      "name": "Bi Qiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/es7qbgsbrywsa.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1980464",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720374/?tool=EBI",
  "id": "es7qbgsbrywsa",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1980464/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7222641951",
  "pdf_url": "https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1980464/pdf",
  "pmcid": "PMC13720374",
  "pmid": "42964390",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/es7qbgsbrywsa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1980464",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1980464/full"
    },
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13720374",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13720374"
    },
    {
      "first_seen": "2026-11-03T12:21:16Z",
      "native_id": "PMC13720374",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fphar.2026.1980464"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1663-9812",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Research on the molecular mechanisms and therapeutic strategies of reactive oxygen species in nasopharyngeal carcinoma",
  "title_text": "Research on the molecular mechanisms and therapeutic strategies of reactive oxygen species in nasopharyngeal carcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:16Z",
  "url": "https://research.draconitic.com/paper/es7qbgsbrywsa",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}