{
  "abstract": "Prostate cancer (PCa) is one of the leading causes of cancer-related death among men worldwide. Considerable efforts have been devoted to developing more effective therapeutic strategies for PCa, particularly for metastatic castration-resistant prostate cancer (mCRPC), wherein resistance to androgen-receptor pathway inhibition remains a major clinical challenge. G protein-coupled receptors (GPCRs), the largest family of cell surface signaling receptors, regulate numerous physiological and pathological processes and represent major therapeutic targets across multiple diseases, including cancer. In PCa, hormone- and inflammation-related GPCRs have emerged as key regulators of tumor initiation, progression, therapeutic resistance, and metastasis. Accordingly, understanding the contribution of GPCR signaling to PCa biology may reveal novel opportunities for therapeutic intervention, particularly in mCRPC. In this review, we summarize the current knowledge on the expression and function of GPCRs in PCa development, progression, and metastasis, highlighting their potential as therapeutic targets and discussing opportunities for drug development, combination therapies, and drug repurposing.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cell Biology, Physiology, and Immunology, University of Córdoba, 14014 Córdoba, Spain",
    "Maimonides Institute for Biomedical Research of Córdoba (IMIBIC), Hospital Universitario Reina Sofía (HURS), 14004 Córdoba, Spain",
    "Universidad Europea de Madrid, Faculty of Biomedical and Health Sciences, Department of Pharmacy and Nutrition, 28670 Madrid, Spain",
    "Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain",
    "Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain",
    "Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain",
    "Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), 28019 Madrid, Spain",
    "The Institute of Cancer Research, London SM2 5GP, UK"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Andre Sarmento-Cabral",
      "orcid": "0000-0002-1204-0371"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Vicente Herrero-Aguayo",
      "orcid": "0000-0002-1631-6312"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Prudencio Sáez-Martínez",
      "orcid": "0000-0001-5909-3553"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Emilia Alors-Pérez",
      "orcid": "0000-0003-1506-7091"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Antonio J. León-González",
      "orcid": "0000-0003-2668-8205"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Juan L. López-Cánovas",
      "orcid": "0000-0001-9032-6124"
    },
    {
      "affs": [
        0,
        1,
        4,
        5
      ],
      "name": "Antonio J. Montero-Hidalgo",
      "orcid": "0000-0002-1948-7512"
    },
    {
      "affs": [
        0,
        1,
        6
      ],
      "name": "Manuel D. Gahete",
      "orcid": "0000-0002-4578-2179"
    },
    {
      "affs": [
        0,
        1,
        7
      ],
      "name": "Juan M. Jiménez-Vacas",
      "orcid": "0000-0003-4391-3726"
    },
    {
      "affs": [
        0,
        1,
        6
      ],
      "name": "Raúl M. Luque",
      "orcid": "0000-0002-7585-1913"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/esbmsaedbwb1k.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209099",
  "fulltext_url": "https://europepmc.org/articles/PMC13704916",
  "id": "esbmsaedbwb1k",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9099",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Prostate Cancer Treatment and Research"
    ]
  ],
  "openalex": "W7221820046",
  "pdf_url": "https://europepmc.org/articles/PMC13704916?pdf=render",
  "pmcid": "PMC13704916",
  "pmid": "42941869",
  "published": "2026-10-14",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/esbmsaedbwb1k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27209099",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9099"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42941869",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42941869"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Prostate Cancer Treatment and Research",
      "subfield": "general"
    }
  ],
  "title": "G Protein-Coupled Receptors in Prostate Cancer: Pathophysiological Implications and Potential for Innovative Therapeutics",
  "title_text": "G Protein-Coupled Receptors in Prostate Cancer: Pathophysiological Implications and Potential for Innovative Therapeutics",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/esbmsaedbwb1k",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}