{
  "abstract": "Metal ions are among the most common enzymatic cofactors, yet metal utilization remains poorly mapped. Here, we present N-Zinclopedia, an atlas of predicted transition metal-binding sites and candidate metalloenzymes across protein fold space. N-Zinclopedia catalogs protein sites compatible with transition metal coordination, identified using ZincSight screening of protein structure model databases. We focused on previously uncharacterized domains and proteins, screening for transition metal-binding sites within over a million of these, spanning both poorly annotated and canonical folds. We also classified the predicted sites, using MAHOMES-II, as candidate catalytic or non-catalytic metal-binding sites. Experimental characterization of a previously unknown zinc binding site confirms that ZincSight can determine previously un-annotated zinc binding. N-Zinclopedia significantly expands the known landscape of metal utilization, providing numerous predictions that await experimental examination. N-Zinclopedia is available at: https://bentallab.github.io/nzinclopedia.",
  "abstract_shown": true,
  "affiliations": [
    "Tel Aviv University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "G. Mechtinger"
    },
    {
      "name": "G. Axel"
    },
    {
      "name": "L. Marcellino"
    },
    {
      "name": "A. M. Bowman"
    },
    {
      "name": "J. Slusky"
    },
    {
      "affs": [
        0
      ],
      "name": "N. Ben-Tal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/esfw9wt0fq0s6.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.18.759936",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759936v1.full",
  "id": "esfw9wt0fq0s6",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759936v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "1312|Protein Structure and Dynamics"
    ]
  ],
  "openalex": "W7222963315",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759936v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/esfw9wt0fq0s6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:32Z",
      "native_id": "10.64898/2026.10.18.759936",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759936v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "N-Zinclopedia: A database of predicted transition metal-binding sites and metalloenzymes",
  "title_text": "N-Zinclopedia: A database of predicted transition metal-binding sites and metalloenzymes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:32Z",
  "url": "https://research.draconitic.com/paper/esfw9wt0fq0s6",
  "venue": "bioRxiv",
  "versions": []
}