{
  "abstract": "Aims\n\nTo compare intraoral (IO) and extraoral (EO) photobiomodulation therapy (PBMT) for preventing oral mucositis (OM) in pediatric patients receiving high-dose methotrexate (HD-MTX).Methods and results\n\nThis prospective, open-label, randomized clinical trial included 75 HD-MTX treatment episodes from 31 pediatric patients aged 1-18 years. Each episode was randomized to IO-PBMT or EO-PBMT with red light at 660 nm. Preventive PBMT was initiated before HD-MTX infusion and administered daily until discharge. OM was assessed at baseline and on days 3, 5, and 10 using the World Health Organization scale. Pain, salivary pH, and salivary biochemical profiles were secondary or exploratory outcomes. Cumulative OM occurred in 22/37 IO-PBMT episodes (59.5%) and 12/38 EO-PBMT episodes (31.6%). After accounting for repeated episodes within patients, OM risk was higher with IO-PBMT (risk ratio, 1.84; 95% CI, 1.07-3.19; p = 0.029). Pain scores, salivary pH, and biochemical profiles did not differ significantly between groups. EO-PBMT required substantially less application time, and no adverse effects were reported.Conclusion\n\nEO-PBMT was associated with lower cumulative OM occurrence, shorter application time, and good tolerability, supporting its use as a promising, less burdensome preventive strategy in pediatric oncology.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Stomatology, Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil.",
    "Pediatric Oncology Department, Hospital Erastinho, Curitiba, Paraná, Brazil.",
    "Institute of Biomedical Sciences, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.",
    "Oncology Department, Hospital Erasto Gaertner, Curitiba, Paraná, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mariana Lena Sassi",
      "orcid": "0009-0003-5467-8351"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicoly Ghilardi Cardoso",
      "orcid": "0000-0002-2629-9034"
    },
    {
      "affs": [
        0
      ],
      "name": "Rafael Zancan Mobile",
      "orcid": "0000-0002-8603-2614"
    },
    {
      "affs": [
        1
      ],
      "name": "Bruna da Fonseca Wastner",
      "orcid": "0000-0002-9056-3733"
    },
    {
      "affs": [
        1
      ],
      "name": "Mara Albonei Dudeque Pianovski",
      "orcid": "0000-0003-0260-8506"
    },
    {
      "affs": [
        2
      ],
      "name": "Robinson Sabino-Silva",
      "orcid": "0000-0002-2104-5780"
    },
    {
      "affs": [
        2
      ],
      "name": "Marco Guevara-Vega",
      "orcid": "0000-0003-2332-0886"
    },
    {
      "affs": [
        2
      ],
      "name": "Douglas Carvalho Caixeta",
      "orcid": "0000-0002-2363-6584"
    },
    {
      "affs": [
        3
      ],
      "name": "Laurindo Moacir Sassi",
      "orcid": "0000-0002-9333-2498"
    },
    {
      "affs": [
        0
      ],
      "name": "Melissa Rodrigues de Araujo",
      "orcid": "0000-0002-2180-8223"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/esh5qz3hw87ag.bib",
  "cited_by": 0,
  "doi": "10.1111/scd.70279",
  "fulltext_url": "https://europepmc.org/articles/PMC13725932",
  "id": "esh5qz3hw87ag",
  "issns": [
    "0275-1879",
    "1754-4505"
  ],
  "landing_url": "https://europepmc.org/article/MED/42969421",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2740|Oral health in cancer treatment"
    ]
  ],
  "openalex": "W7225106855",
  "pdf_url": "https://europepmc.org/articles/PMC13725932?pdf=render",
  "pmcid": "PMC13725932",
  "pmid": "42969421",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/esh5qz3hw87ag.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42969421",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42969421"
    },
    {
      "first_seen": "2026-11-05T12:22:23Z",
      "native_id": "PMC13725932",
      "source": "pmc",
      "url": "https://doi.org/10.1111/scd.70279"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Oral health in cancer treatment",
      "subfield": "general"
    }
  ],
  "title": "Extraoral Versus Intraoral Photobiomodulation for the Prevention of Oral Mucositis in Pediatric Patients Undergoing High-Dose Methotrexate Chemotherapy.",
  "title_text": "Extraoral Versus Intraoral Photobiomodulation for the Prevention of Oral Mucositis in Pediatric Patients Undergoing High-Dose Methotrexate Chemotherapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:00Z",
  "url": "https://research.draconitic.com/paper/esh5qz3hw87ag",
  "venue": "Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry",
  "versions": []
}