{
  "abstract": "Neural mechanisms underlying sexually dimorphic social behaviors remain enigmatic in most species. In Drosophila, sexually dimorphic pC1/pC1x neurons have been described as a site of sensory integration that regulates mating and aggressive behaviors. We show that the male pC1/pC1x population resides in an expansive and highly intertwined male-specific network that is poised to regulate social behavior. The 48 pC1/pC1x connectomically defined cell types exhibit heterogeneous synaptic connections, and a subset receive strong input from identified sensory pathways. Genetic driver lines for these cell types were generated and used to discover distinct roles for pC1/pC1x cell types in modulating social acoustic signaling and male-male interactions. We also describe circuit motifs by which pC1 and sexually dimorphic aIPg neurons co-regulate social behaviors. Our results reveal unexpected diversity in the connectivity and behavioral roles of pC1/pC1x cell types and provide essential genetic tools for interrogating their neurophysiological and behavioral functions.",
  "abstract_shown": true,
  "affiliations": [
    "Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA; FlyEM Project Team, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA. Electronic address: rubing@janelia.hhmi.org",
    "Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA",
    "Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA. Electronic address: otopalika@janelia.hhmi.org"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gerald M. Rubin",
      "orcid": "0000-0001-8762-8703"
    },
    {
      "affs": [
        1
      ],
      "name": "Claire Managan",
      "orcid": "0000-0002-9510-6443"
    },
    {
      "affs": [
        1
      ],
      "name": "Marisa Dreher",
      "orcid": "0000-0002-0041-9229"
    },
    {
      "affs": [
        1
      ],
      "name": "Elizabeth Kim",
      "orcid": "0000-0002-6961-4903"
    },
    {
      "affs": [
        1
      ],
      "name": "Scott W. Miller",
      "orcid": "0009-0009-8503-4536"
    },
    {
      "affs": [
        1
      ],
      "name": "Kaitlyn Nicole Boone"
    },
    {
      "affs": [
        1
      ],
      "name": "Alice A. Robie",
      "orcid": "0000-0002-0784-2927"
    },
    {
      "affs": [
        1
      ],
      "name": "Adam L. Taylor",
      "orcid": "0009-0005-4622-037X"
    },
    {
      "affs": [
        1
      ],
      "name": "Kristin M. Branson",
      "orcid": "0000-0002-5567-2512"
    },
    {
      "affs": [
        1
      ],
      "name": "Catherine E. Schretter",
      "orcid": "0000-0002-3957-6838"
    },
    {
      "affs": [
        2
      ],
      "name": "Adriane G. Otopalik",
      "orcid": "0000-0002-3224-6502"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/esqyemk614t09.bib",
  "cited_by": 5,
  "doi": "10.1016/j.cub.2026.08.013",
  "fulltext_url": null,
  "id": "esqyemk614t09",
  "issns": [
    "0960-9822",
    "1879-0445"
  ],
  "landing_url": "https://doi.org/10.1016/j.cub.2026.08.013",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Neurobiology and Insect Physiology Research"
    ]
  ],
  "openalex": "W7207638311",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42692022",
  "published": "2026-09-01",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/esqyemk614t09.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T13:20:36Z",
      "native_id": "W7207638311",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.cub.2026.08.013"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Neurobiology and Insect Physiology Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Networks of sexually dimorphic neurons that regulate social behaviors in Drosophila",
  "title_text": "Networks of sexually dimorphic neurons that regulate social behaviors in Drosophila",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:49Z",
  "url": "https://research.draconitic.com/paper/esqyemk614t09",
  "venue": "Current Biology",
  "versions": []
}