{
  "abstract": "Background\n\nCircumscribed choroidal hemangioma (CCH) is a benign vascular choroidal tumor traditionally characterized on ultrasonography by dome-shaped morphology, acoustic solidity, and high internal reflectivity. Dynamic features on real-time B-scan ultrasonography have not been systematically evaluated. This study aimed to characterize the prevalence of intralesional flickering on real-time dynamic B-scan ultrasonography in treatment-naive CCH and to evaluate its relationship to tumor dimensions and exudative activity.Methods\n\nThis retrospective observational study included 29 treatment-naive eyes of 29 patients diagnosed with CCH at a tertiary ocular oncology service between 2015 and 2025. Standardized B-scan ultrasonography at 10 MHz, with real-time documentation of intralesional flickering, was performed per departmental protocol. Tumor largest basal diameter (LBD) and thickness were measured. Spectral-domain optical coherence tomography was reviewed for subretinal and intraretinal fluid. Associations between flickering status and tumor dimensions, exudative fluid, and tumor location were assessed.Results\n\nMean age was 55.1 years, 75.9% of patients were male, and 65.5% of tumors were macular. Flickering was identified in 17 of 29 eyes (58.6%). Tumors with flickering had a significantly greater largest basal diameter than tumors without flickering (9.27 versus 6.34 mm; p < 0.001) and a trend toward greater thickness (3.00 versus 2.21 mm; p = 0.073). Fluid on optical coherence tomography was present in 24 eyes (82.8%) and was associated with greater LBD (p = 0.022) and greater tumor thickness (p = 0.027). Fluid was more prevalent in eyes with flickering than in those without flickering (94.1% versus 66.7%; p = 0.130). Tumor location was not significantly associated with flickering status or fluid presence.Conclusions\n\nIntralesional flickering on real-time dynamic B-scan ultrasonography is detectable in more than half of treatment-naive CCH and correlates with tumor size, warranting further evaluation as a potential dynamic imaging feature of the lesion.Trial registration\n\nNot applicable.",
  "abstract_shown": true,
  "affiliations": [
    "Goldschleger Eye Institute, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel. mirifoglevin@gmail.com.",
    "Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. mirifoglevin@gmail.com.",
    "Goldschleger Eye Institute, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.",
    "Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Miri Meira Fogel Levin",
      "orcid": "0000-0003-3797-1938"
    },
    {
      "affs": [
        2
      ],
      "name": "Abed Elmajed Haj Yahya"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Avner Hostovsky"
    },
    {
      "affs": [
        2
      ],
      "name": "Iris Moroz"
    },
    {
      "affs": [
        2
      ],
      "name": "Yael Birger"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Ido Didi Fabian"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Vicktoria Vishnevskia Dai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/et11zc585pw6g.bib",
  "cited_by": 0,
  "doi": "10.1186/s40942-026-00915-1",
  "fulltext_url": "https://europepmc.org/articles/PMC13726008",
  "id": "et11zc585pw6g",
  "issns": [
    "2056-9920"
  ],
  "landing_url": "https://europepmc.org/article/MED/42968135",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2731|Ocular Oncology and Treatments"
    ]
  ],
  "openalex": "W7172400258",
  "pdf_url": "https://europepmc.org/articles/PMC13726008?pdf=render",
  "pmcid": "PMC13726008",
  "pmid": "42968135",
  "published": "2026-08-04",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/et11zc585pw6g.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:54Z",
      "native_id": "MED:42968135",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42968135"
    },
    {
      "first_seen": "2026-11-05T12:22:26Z",
      "native_id": "PMC13726008",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s40942-026-00915-1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2741|Retinal and Macular Surgery",
      "subfield": "imaging"
    }
  ],
  "title": "Intralesional flickering in circumscribed choroidal hemangioma: prevalence and association with tumor size.",
  "title_text": "Intralesional flickering in circumscribed choroidal hemangioma: prevalence and association with tumor size.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:04Z",
  "url": "https://research.draconitic.com/paper/et11zc585pw6g",
  "venue": "International journal of retina and vitreous",
  "versions": []
}