{
  "abstract": "BACKGROUND: This study investigated whether small dense low-density lipoprotein cholesterol (sdLDL-C) can predict long-term coronary artery disease (CAD) events in patients with stable CAD without metabolic dyslipidemia. METHODS AND RESULTS: Directly measured sdLDL-C was evaluated in 396 male and 144 female patients with stable CAD who had high-density lipoprotein cholesterol (HDL-C) ≥40 mg/dL and triglyceride <150 mg/dL. CAD events, which were defined as sudden cardiac death, acute coronary syndrome onset, and/or a need for coronary revascularization, were monitored for 12 years. First-time CAD events were observed in 110 men and 44 women. Kaplan-Meier event-free survival curves showed that patients with sdLDL-C ≥32.5 mg/dL (top quartile) had an increased risk of CAD events (log-rank P=0.009). The multivariate-adjusted hazard ratio (HR) in the top sdLDL-C quartile was 1.632 (95% confidence interval 1.159-2.297) and remained significant in 354 patients treated with statins (HR 1.582; P=0.041), whereas the risk in the top quartiles of LDL-C, non-HDL-C, apolipoprotein B, and triglyceride was not significantly higher relative to lower quartiles. Receiver operating characteristic curve analyses indicated that risk increased at cut-off values of sdLDL-C ≥32.2 mg/dL (HR 1.566; P=0.011) and sdLDL-C/LDL-C ratio ≥0.316 (HR 1.569; P=0.018). CONCLUSIONS: Although sdLDL is a feature of metabolic dyslipidemia, high sdLDL-C can predict long-term recurrence of CAD events even in patients without metabolic dyslipidemia.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Shinji Koba"
    },
    {
      "name": "Yuya Yokota"
    },
    {
      "name": "Noriyuki Satoh"
    },
    {
      "name": "Yasuki Ito"
    },
    {
      "name": "Fumiyoshi Tsunoda"
    },
    {
      "name": "Koshiro Sakai"
    },
    {
      "name": "Yuya Nakamura"
    },
    {
      "name": "Makoto Shoji"
    },
    {
      "name": "Tsutomu Hirano"
    },
    {
      "name": "Toshiro Shinke"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/etxn77bjddbj6.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-25-0805",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0805/_article",
  "id": "etxn77bjddbj6",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0805/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7154741437",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-25-0805/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/etxn77bjddbj6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-25-0805",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0805/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "Small Dense Low-Density Lipoprotein Cholesterol Predicts Long-Term Coronary Artery Disease Recurrence in Patients Without Metabolic Dyslipidemia",
  "title_text": "Small Dense Low-Density Lipoprotein Cholesterol Predicts Long-Term Coronary Artery Disease Recurrence in Patients Without Metabolic Dyslipidemia",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/etxn77bjddbj6",
  "venue": "Circulation Journal",
  "versions": []
}