{
  "abstract": "Significance: Continuous, non-invasive monitoring of cardiovascular physiology provides critical information for clinical decision-making and patient care. Emerging optical sensors enable non-contact measurement of physiological parameters such as heart rate and respiratory rate, but current methods are limited in their ability to capture spatially resolved physiological waveforms. Aim: We aimed to extend the capabilities of non-contact cardiovascular monitoring by using an imaging-based approach from which spatially resolved physiological waveforms can be extracted and cardiovascular biomarkers can be derived in vivo. Approach: We implemented a digital holographic imaging sensor to continuously measure calibrated tissue motion for in vivo assessment of cardiovascular biomarkers in six adult male Sprague-Dawley rats, with validation against electrocardiographic and invasive arterial blood pressure measurements. Results: Heart rate and pulse arrival time-derived pulse wave velocity calculated from digital holographic imaging demonstrate strong agreement with reference-derived metrics (concordance correlation coefficient [≥] 0.98). Heart rate variability shows moderate agreement with reference-derived metrics (concordance correlation coefficient [≥] 0.59).",
  "abstract_shown": true,
  "affiliations": [
    "Johns Hopkins University School of Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "A. T. Lefebvre"
    },
    {
      "name": "N. E. Steiner"
    },
    {
      "name": "S. Wang"
    },
    {
      "name": "C. L. Rodriguez"
    },
    {
      "name": "E. Bar-Kochba"
    },
    {
      "name": "Y. Shi"
    },
    {
      "name": "S.-M. Cho"
    },
    {
      "name": "D. W. Blodgett"
    },
    {
      "name": "M. Mirski"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ev0wfzht4ssvc.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.04.749131",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.04.749131v1.full",
  "id": "ev0wfzht4ssvc",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.04.749131v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioengineering"
    ],
    [
      "openalex",
      "2204|Non-Invasive Vital Sign Monitoring"
    ]
  ],
  "openalex": "W7212267569",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.04.749131v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ev0wfzht4ssvc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:17Z",
      "native_id": "10.64898/2026.09.04.749131",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.04.749131v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioengineering",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Non-contact optical imaging of tissue deformation enables in vivo cardiovascular monitoring",
  "title_text": "Non-contact optical imaging of tissue deformation enables in vivo cardiovascular monitoring",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:17Z",
  "url": "https://research.draconitic.com/paper/ev0wfzht4ssvc",
  "venue": "bioRxiv",
  "versions": []
}