{
  "abstract": "BACKGROUND: Diastolic dysfunction is a recognized chronic allograft complication, and a restrictive left ventricular filling pattern is associated with adverse outcomes. However, the underlying pathophysiological mechanisms remain unclear. METHODS AND RESULTS: <0.05), in the restrictive group at 5 years. Temporal analysis revealed that these pathways were downregulated from 1 to 5 years in the non-restrictive group but remained persistently activated in the restrictive group. CONCLUSIONS: The development of a restrictive filling pattern is associated with elevated intracardiac pressures and a persistent immune-related transcriptome signature, despite no histological evidence of rejection.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Kosuke Takahari"
    },
    {
      "name": "Tatsuya Shiraki"
    },
    {
      "name": "Hidetaka Kioka"
    },
    {
      "name": "Daisuke Nakamura"
    },
    {
      "name": "Yasuhiro Akazawa"
    },
    {
      "name": "Kei Nakamoto"
    },
    {
      "name": "Yuki Kuramoto"
    },
    {
      "name": "Hibiki Mima"
    },
    {
      "name": "Fusako Sera"
    },
    {
      "name": "Yasuharu Takeda"
    },
    {
      "name": "Yasumasa Tsukamoto"
    },
    {
      "name": "Isamu Mizote"
    },
    {
      "name": "Yusuke Adachi"
    },
    {
      "name": "Tomoyo Hamana"
    },
    {
      "name": "Tomohito Ohtani"
    },
    {
      "name": "Shigeru Miyagawa"
    },
    {
      "name": "Yasushi Sakata"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/evhvre0zb9a1r.bib",
  "cited_by": 3,
  "doi": "10.1253/circj.cj-26-0427",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0427/_article",
  "id": "evhvre0zb9a1r",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0427/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2746|Transplantation: Methods and Outcomes"
    ]
  ],
  "openalex": "W7203840065",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0427/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/evhvre0zb9a1r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-26-0427",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0427/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Transplantation: Methods and Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation",
  "title_text": "Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/evhvre0zb9a1r",
  "venue": "Circulation Journal",
  "versions": []
}