{
  "abstract": "The N -CF 2 H motif recently emerges as a promising pharmacophore but modular and general strategy to access this scaffold remains scarce. Although difluoromethyl azide (HCF 2 N 3 ) constitutes an ideal aminodifluoromethyl surrogate in this case, its exceptionally low ratio of C to N atoms (0.33), high volatility (b.p. = 8 o C), and heat/shock sensitivity render it particularly unsafe to handle and use in batch. On the other hand, R-22 (ClCF 2 H gas) is a phased-out refrigerent due to its ozone depletion potential and high global warming potential, and valorization of the reclaimed R-22 is highly desirable. Here, we report a modular continuous flow platform to efficiently enable a safe, on-demand generation of HCF 2 N 3 from R-22 gas and its direct in-line utilization. Two HCF 2 N 3 generation modules are developed to operate under aqueous or organic reaction conditions for accommodating diverse downstream reactions. The freshly generated HCF 2 N 3 is immediately intercepted by downstream base-mediated or copper tube-catalyzed cycloadditions to yield a wide range of valuable N -CF 2 H triazoles using easily available alkynes, aldehydes and β -ketoesters. Our method completely circumvents isolation hazards, mass transfer limitations in batch, and enables previously improbable gas-to-gas transformation and multiphasic conditions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China",
    "China Chemical Technology Research Institute"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ye Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianbo Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wai Chung Fu",
      "orcid": "0000-0002-7181-0057"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/evqkwnppagp3r.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010927/v1",
  "fulltext_url": null,
  "id": "evqkwnppagp3r",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010927/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7223373370",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010927/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/evqkwnppagp3r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.26434/chemrxiv.15010927",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010927/v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "A Modular Continuous Flow Platform for Safe, On-demand Generation of HCF ₂ N ₃ from R-22 Gas and Access to N -CF ₂ H Triazoles",
  "title_text": "A Modular Continuous Flow Platform for Safe, On-demand Generation of HCF ₂ N ₃ from R-22 Gas and Access to N -CF ₂ H Triazoles",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/evqkwnppagp3r",
  "venue": "ChemRxiv",
  "versions": []
}