{
  "abstract": "While 6-PPD quinone (6-PPDQ) is known for its acute lethality to salmonids, its chronic impacts on non-target species remain elusive. Here, we evaluated the chronic toxicity of 6-PPDQ across multiple biological models. Our results demonstrate that 6-PPDQ exposure significantly curtailed the survival and physiological motility of the nematode Caenorhabditis elegans, while inducing cellular senescence-associated biomarkers and a secretory phenotype (SASP) in human MRC-5 cells. In adult zebrafish, chronic exposure over a 28-month follow-up window precipitated cognitive and neurobehavioral deficits, characterized by impaired spatial learning, elevated agonistic reactivity, and glutamatergic excitotoxicity. Through computational screening, molecular docking, and pharmacological rescue, we identified ABL1 as a prioritized candidate target and functional mediator of 6-PPDQ toxicity. Total ABL1 protein abundance was elevated in exposed zebrafish brains alongside p53 accumulation and autophagic substrate (p62 and LC3-II) retention. Importantly, concurrent treatment with the ABL1 kinase inhibitor nilotinib attenuated p53 induction, restored autophagic flux, and rescued locomotor deficits, implicating the ABL1-associated pathway in these phenotypes. Because overt organismal morbidity was manifest predominantly at upper-bound exposure concentrations (10 µg/L), these phenotypes reflect chronic toxic stress rather than an acceleration of natural aging. These findings identify an ABL1-associated mechanism of chronic neurotoxicity and emphasize the need to assess long-term neurological risks associated with tire-wear pollution.",
  "abstract_shown": true,
  "affiliations": [
    "School of Basic Medical Sciences, Xinjiang Second Medical College, Karamay, China",
    "College of Life Sciences, Nanjing Agricultural University, China",
    "School of Basic Medical Sciences, Xinjiang Second Medical College, Karamay, China; School of Pharmacy, Xinjiang Second Medical College, Karamay, China; Corresponding author at: School of Pharmacy, Xinjiang Second Medical College, Karamay, China.",
    "Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China; Corresponding author."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zejiang Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Manxue Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Chunmei Xia"
    },
    {
      "affs": [
        2
      ],
      "name": "Jianguang Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Jian Lu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/evscb5crv8x7s.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ecoenv.2026.120962",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S0147651326012923",
  "id": "evscb5crv8x7s",
  "issns": [
    "0147-6513",
    "1090-2414"
  ],
  "landing_url": "https://doi.org/10.1016/j.ecoenv.2026.120962",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "GE1-350"
    ],
    [
      "lcc",
      "TD172-193.5"
    ],
    [
      "openalex",
      "2307|Toxic Organic Pollutants Impact"
    ]
  ],
  "openalex": "W7223240098",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/evscb5crv8x7s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:35Z",
      "native_id": "a2c423b216d442ff82c327d4cf48a78d",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.ecoenv.2026.120962"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Toxic Organic Pollutants Impact",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Chronic exposure to the tire-wear contaminant 6-PPDQ induces senescence-associated biomarkers and neurobehavioral deficits: Involvement of ABL1-p53-autophagy signaling",
  "title_text": "Chronic exposure to the tire-wear contaminant 6-PPDQ induces senescence-associated biomarkers and neurobehavioral deficits: Involvement of ABL1-p53-autophagy signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:35Z",
  "url": "https://research.draconitic.com/paper/evscb5crv8x7s",
  "venue": "Ecotoxicology and Environmental Safety",
  "versions": []
}