{
  "abstract": "Propofol and fospropofol are used in pediatric surgical anesthesia, but their comparative developmental safety remains uncertain. In this study, zebrafish embryos were exposed to equianesthetic concentrations of propofol or fospropofol. Embryonic survival, hatching, malformation, and post-anesthesia motor behavior were assessed. RNA sequencing and molecular docking were performed to explore potential molecular mechanisms. Fospropofol exhibited lower developmental toxicity than propofol, as shown by the higher survival and hatching rates and a lower malformation rate. Comparative toxicogenomic analysis revealed distinct molecular pathways and candidate targets that may underlie these differential effects. Collectively, these zebrafish data suggest a favorable developmental safety profile for fospropofol and underscore the need for dose optimization and monitoring in pediatric anesthetic management; validation in mammalian models and controlled human studies is further warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.",
    "Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an 710049, China.",
    "Cardiovascular Research Center, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhe Liu",
      "orcid": "0000-0002-7137-1883"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingying Deng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuanye Gao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chunyu Jia"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xueqi Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Leyan Tao"
    },
    {
      "affs": [
        2
      ],
      "name": "Baochang Lai"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyan Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yansong Li",
      "orcid": "0000-0003-4949-0576"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yue Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaomin Zhu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/evtsdrkrhsnek.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198494",
  "fulltext_url": "https://europepmc.org/articles/PMC13665160",
  "id": "evtsdrkrhsnek",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883742",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2806|Anesthesia and Neurotoxicity Research"
    ]
  ],
  "openalex": "W7214122562",
  "pdf_url": "https://europepmc.org/articles/PMC13665160?pdf=render",
  "pmcid": "PMC13665160",
  "pmid": "42883742",
  "published": "2026-09-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/evtsdrkrhsnek.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883742",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883742"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2806|Anesthesia and Neurotoxicity Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Differential Neurodevelopmental Toxicity of Propofol and Fospropofol: Mechanistic Insights and Potential Clinical Implications-A Zebrafish Model Study.",
  "title_text": "Differential Neurodevelopmental Toxicity of Propofol and Fospropofol: Mechanistic Insights and Potential Clinical Implications-A Zebrafish Model Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/evtsdrkrhsnek",
  "venue": "International journal of molecular sciences",
  "versions": []
}