{
  "abstract": "Intracellular confinement suppresses the dynamic magnetic losses of nanoparticles after uptake, limiting their efficacy under alternating magnetic fields (AMF). A crystalline metal-organic framework (MOF) shell limits this collapse by enforcing a minimum interparticle spacing that restricts the dipolar coupling imposed by endosomal packing. A conformal UiO-66 shell about 9 nm thick grows directly on poly(ethylene glycol) (PEG)-silane-stabilized Fe3O4 nanocubes at room temperature without N,N- dimethylformamide, giving single-core nanocomposites. AC hysteresis measurements in A549 lung cancer cells show that internalization collapses the loop of PEG-coated nanocubes, which retain only 12% of their aqueous specific loss power (SLP) and 28% of their remanence ratio Mr/Mmax, whereas the MOF-shelled counterparts retain 40% and 47%. Recovering the nanoparticles from the lysed cells reopens the collapsed loops and restores Mr/Mmax to 81% and 89% of the aqueous reference, placing the origin of the loss in the spacing between cores rather than in their degradation. Under safety- compliant AMF, cells containing the nanocomposites lose metabolic activity, reaching 38% of the untreated control by day 7 despite a bulk temperature rise of 1 °C, a response absent in PEG-coated 2 particles at a matched intracellular iron load. Interparticle spacing therefore emerges as a design parameter for intracellular magnetic energy dissipation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Josef Kopp",
      "orcid": "0000-0002-5339-0570"
    },
    {
      "name": "Giulia Zampini"
    },
    {
      "name": "Samuel Funes-Hernando"
    },
    {
      "name": "Manuel Ceballos"
    },
    {
      "name": "Sajid Fazal"
    },
    {
      "name": "José Manuel Vila-Fungueiriño"
    },
    {
      "name": "Beatriz Pelaz"
    },
    {
      "name": "Pablo del Pino"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/evx1wfa579bh6.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010448/v1",
  "fulltext_url": null,
  "id": "evx1wfa579bh6",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010448/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Characterization and Applications of Magnetic Nanoparticles"
    ]
  ],
  "openalex": "W7221803586",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010448/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/evx1wfa579bh6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010448",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010448/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "source:chemrxiv",
      "subfield": "general"
    }
  ],
  "title": "Metal-Organic Framework Shells Limit the Intracellular Collapse of AC Hysteresis in Magnetite Nanocubes",
  "title_text": "Metal-Organic Framework Shells Limit the Intracellular Collapse of AC Hysteresis in Magnetite Nanocubes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/evx1wfa579bh6",
  "venue": "ChemRxiv",
  "versions": []
}