{
  "abstract": "Objective: To elucidate the bioactive compounds and cardioprotective mechanism of Huangqishengmaiyin (HQSMY) against anthracycline-induced cardiotoxicity (AIC) in breast cancer with concomitant gut microbiota modulation.\n\nMethods: Myocardial fibrosis was quantified using Masson's trichrome staining. Hematoxylin and eosin staining was used for general histopathological evaluation. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-Q Exactive HFX) was employed to comprehensively identify blood components in HQSMY. The regulatory effect of HQSMY on the gut microbiota of AIC mice was assessed by 16S rRNA microbial sequencing. Network pharmacology and molecular docking mapped the compound-target-pathway network. Western blot was performed to detect key proteins in the predicted pathways, including JAK1, STAT3, and HIF-1α.\n\nResults: HQSMY reduced myocardial fibrosis rates, enhanced gut microbiota diversity, abundance and health indices. Meanwhile, HQSMY increased the abundance of anti-inflammatory bacteria like Bacteroidetes and restored normal metabolic pathways in multiple gut microbes, including glycolysis. 42 blood components were identified, exhibiting antioxidant, anti-inflammatory, and gut microbiota-regulating activities. Network pharmacology analysis revealed that the JAK-STAT and HIF-1 signaling pathways are key mechanisms. Enrichment analysis focused on energy metabolism and inflammatory response. Western blot results confirmed that HQSMY significantly downregulated JAK1 and HIF-1α protein expression; STAT3 was decreased without reaching statistical significance.\n\nConclusion: The components of HQSMY exhibit anti-inflammatory effects in myocardial tissue, meanwhile enhancing beneficial gut bacteria in intestine. The regulatory effect of HQSMY may be exerted through JAK-STAT and HIF-1 pathways, as confirmed by altered expression of key proteins in these pathways.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Breast Surgery, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China",
    "Fifth Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China",
    "First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China",
    "College of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, China",
    "College of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yixuan Wang"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yeying Jin"
    },
    {
      "affs": [
        3
      ],
      "name": "Jiali Han"
    },
    {
      "affs": [
        4
      ],
      "name": "Mingjia Ding"
    },
    {
      "affs": [
        3
      ],
      "name": "Haoqing Hou"
    },
    {
      "affs": [
        4
      ],
      "name": "Miaoyu Mei"
    },
    {
      "affs": [
        0
      ],
      "name": "Rui Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ew5fx5tzw2q7n.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.1818551",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696217/",
  "id": "ew5fx5tzw2q7n",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://doi.org/10.3389/fcvm.2026.1818551",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
    ]
  ],
  "openalex": "W7221452023",
  "pdf_url": "https://europepmc.org/articles/PMC13696217?pdf=render",
  "pmcid": "PMC13696217",
  "pmid": "42935682",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ew5fx5tzw2q7n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "PMC13696217",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcvm.2026.1818551"
    },
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "10.3389/fcvm.2026.1818551",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1818551/full"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42935682",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935682"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Exploring the protective mechanism of Huangqishengmaiyin against anthracycline-induced cardiotoxicity in breast cancer with concomitant gut microbiota modulation",
  "title_text": "Exploring the protective mechanism of Huangqishengmaiyin against anthracycline-induced cardiotoxicity in breast cancer with concomitant gut microbiota modulation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:35Z",
  "url": "https://research.draconitic.com/paper/ew5fx5tzw2q7n",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}