{
  "abstract": "Background: Sympathetic innervation is fundamentally required for physiological aortic homeostasis. Though it plays a vital important role in aortic function, its specific role in aortic dissection (AD) remains unclear. Methods and results: In this study, we explored the role of the sympathetic nervous system in AD by examining the effects of superior cervical ganglionectomy (SCGx) in mice. Using β-aminopropionitrile (BAPN) induced AD mice model at pre-lesional stage, the tyrosine hydroxylase (TH) expression, indicative of sympathetic activity, increased early in AD progression and correlated with aortic elastic lamina degradation. SCGx did not affect aortic structure within 2 weeks without BAPN treatment, but bilateral SCGx exacerbated AD severity, increasing rupture rates and tear range after BAPN and angiotensin II (AngII) treatment. Conclusions: These findings highlighted the role of sympathetic nervous system in early AD stages and suggested bilateral SCGx may negatively impact AD progression. Furthermore, we found a trend toward smooth muscle cell phenotypic transformation after implementing SCGx in AD, revealing the integrity of the SCG played a pivotal role in preserving aortic homeostasis.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China",
    "School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China",
    "School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China",
    "Shenzhen Institute for Drug Control (Shenzhen Testing Center of Medical Devices), Shenzhen, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhonghui Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Hao Jin"
    },
    {
      "affs": [
        2
      ],
      "name": "Jie Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Li Yu"
    },
    {
      "name": "Meifang Cao"
    },
    {
      "name": "Tao Jiang"
    },
    {
      "name": "Yi Jin"
    },
    {
      "name": "Baohong Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ewat4gqk8ac2w.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0357281",
  "fulltext_url": null,
  "id": "ewat4gqk8ac2w",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0357281",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Aortic Disease and Treatment Approaches"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Biological tissue/Muscle tissue/Muscle cells/Smooth muscle cells"
    ],
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      "plos",
      "/Biology and life sciences/Anatomy/Biological tissue/Nerve tissue/Ganglia"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Aorta"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Nervous system/Nerve tissue/Ganglia"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Nervous system/Peripheral nervous system/Autonomic nervous system/Sympathetic nervous system"
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    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular types/Animal cells/Muscle cells/Smooth muscle cells"
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      "plos",
      "/Biology and life sciences/Immunology/Immune response/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Biological tissue/Muscle tissue/Muscle cells/Smooth muscle cells"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Biological tissue/Nerve tissue/Ganglia"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Aorta"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Nervous system/Nerve tissue/Ganglia"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Nervous system/Peripheral nervous system/Autonomic nervous system/Sympathetic nervous system"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune response/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures/Cardiovascular procedures/Vascular surgery"
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      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Animal models/Mouse models"
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      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Model organisms/Mouse models"
    ],
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      "plos",
      "/Research and analysis methods/Model organisms/Mouse models"
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      "plos",
      "/Research and analysis methods/Specimen preparation and treatment/Staining/Cell staining"
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357281&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/ewat4gqk8ac2w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "10.1371/journal.pone.0357281",
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      "url": "https://doi.org/10.1371/journal.pone.0357281"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Superior cervical gangliectomy exacerbates the aortic dissection in mice",
  "title_text": "Superior cervical gangliectomy exacerbates the aortic dissection in mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/ewat4gqk8ac2w",
  "venue": "PLOS One",
  "versions": []
}