{
  "abstract": "Background\n\nThe rising incidence of colorectal cancer (CRC) and cardiovascular diseases, driven by aging populations and lifestyle changes, highlights congestive heart failure (CHF) as a critical comorbidity that significantly affects survival and treatment decisions in CRC patients. CHF not only affects survival outcomes but also complicates clinical decision-making. This study aims to investigate the impact of CHF on mortality among CRC survivors and explore potential factors of mortality.Methods\n\nThis cohort study analyzed data from the Taiwan Cancer Registry and National Health Insurance Research Database. CRC patients aged 20 years or older (ICD-10-CM: C18-C20) who survived at least five years after diagnosis were included. After a 1:4 exact matching based on age, sex, and clinical stage, Cox regression was used to estimate mortality risk between CRC survivors with and without CHF.Results\n\nA total of 535 CRC survivors with CHF and 2140 without CHF were enrolled in this study after matching. CRC survivors with CHF had a significantly higher overall mortality rate than those without CHF (36.64% vs. 15.23%, p < 0.001). After adjusting for potential confounders, CRC survivors with CHF had 1.93-folds risk of mortality (95% CI: 1.54-2.41, p < 0.001) compared to those without CHF. Subgroup analyses by sex, age, clinical stage, Charlson Comorbidity Index (CCI), and treatment types also show that CRC survivors with CHF had significantly higher mortality risk than those without CHF. The top three highest mortality risk ratios were observed in subgroups with a CCI score of 0 (AHR: 2.63, 95% CI: 1.08-6.39), age < 65 years (AHR: 1.87, 95% CI: 1.23-5.57), and advanced clinical stage (AHR: 2.03, 95% CI: 1.51-2.72).Conclusion\n\nCRC survivors with CHF demonstrated significantly higher overall mortality compared to those without CHF. This finding presented the prognostic impact of CHF in CRC survivors, so integrated care and early cardiovascular monitoring are essential to improve long-term outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.",
    "Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.",
    "Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan.",
    "Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.",
    "Cancer Center, Chi Mei Medical Center, Tainan, Taiwan.",
    "Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.",
    "Division of Hematology‑Oncology, Department of Internal Medicine, Chi Mei Hospital, Liouying District, Tainan, Taiwan.",
    "Department of Medical Research, Chi Mei Medical Center Tainan, Tainan City, Taiwan.",
    "Department of Medical Research, Chi Mei Medical Center Tainan, Tainan City, Taiwan. ho.c.hank@gmail.com.",
    "Department of Information Management, Southern Taiwan University of Science and Technology, Tainan, Taiwan. ho.c.hank@gmail.com.",
    "Cancer Center, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei, Taiwan. ho.c.hank@gmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mitsuhiro Koseki"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Ching-Chieh Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "I-Che Feng"
    },
    {
      "affs": [
        5
      ],
      "name": "Wei-Chieh Lee"
    },
    {
      "affs": [
        6
      ],
      "name": "Chien-Liang Lin"
    },
    {
      "affs": [
        7
      ],
      "name": "Ying-Jia Lin"
    },
    {
      "affs": [
        7
      ],
      "name": "Jhi-Joung Wang"
    },
    {
      "affs": [
        8,
        9,
        10
      ],
      "name": "Chung-Han Ho",
      "orcid": "0000-0001-5925-8477"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ewfn31xrs3wry.bib",
  "cited_by": 0,
  "doi": "10.1186/s12885-026-16717-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13753211",
  "id": "ewfn31xrs3wry",
  "issns": [
    "1471-2407"
  ],
  "landing_url": "https://europepmc.org/article/MED/43009806",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
    ]
  ],
  "openalex": "W7202247468",
  "pdf_url": "https://europepmc.org/articles/PMC13753211?pdf=render",
  "pmcid": "PMC13753211",
  "pmid": "43009806",
  "published": "2026-08-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ewfn31xrs3wry.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43009806",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43009806"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Assessing mortality risk in colorectal cancer survivors with congestive heart failure: a cohort study from the Taiwan Cancer Registry.",
  "title_text": "Assessing mortality risk in colorectal cancer survivors with congestive heart failure: a cohort study from the Taiwan Cancer Registry.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T03:20:45Z",
  "url": "https://research.draconitic.com/paper/ewfn31xrs3wry",
  "venue": "BMC cancer",
  "versions": []
}