{
  "abstract": "Background/Objectives: Anti-CD38 monoclonal antibody-based quadruplets have increased measurable residual disease (MRD) negativity rates in newly diagnosed multiple myeloma, questioning the incremental benefit of upfront autologous stem cell transplantation (ASCT). Methods: We performed a systematic review and frequentist random-effects network meta-analysis (NMA) of randomized trials reporting MRD negativity by treatment arm; sustained MRD (sMRD) negativity was analyzed by pairwise meta-analysis. Results: Seventeen trials (6293 patients; 13 strategies) were included. Anti-CD38–KRd (SUCRA 89.1%), anti-CD38–VRd + ASCT (88.0%) and anti-CD38–KRd + ASCT (86.5%) ranked highest for MRD negativity, with no statistically significant difference among them. No comparison between a strategy with and without ASCT reached statistical significance (VRd + ASCT vs. VRd: OR 1.72, 95% CI 0.95–3.10). There was no evidence of inconsistency, and rankings were consistent across sensitivity analyses. Adding an anti-CD38 antibody to the same backbone increased the odds of sMRD negativity in both transplant-eligible (OR 3.05, 95% CI 1.32–7.03) and transplant-ineligible populations (3.26, 2.18–4.88; p for interaction = 0.88). No sMRD data allowed a comparison between transplant and non-transplant quadruplet strategies. Conclusions: Anti-CD38-based quadruplets offer the highest probability of achieving MRD negativity and improve its persistence regardless of transplant eligibility, whereas the incremental contribution of ASCT in the quadruplet era remains uncertain.",
  "abstract_shown": true,
  "affiliations": [
    "Haematology Unit, Renato Dulbecco Hospital, 88100 Catanzaro, Italy",
    "Department of Hematology-Oncology, Azienda Ospedaliera Renato Dulbecco, 88100 Catanzaro, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Giulio Caridà",
      "orcid": "0000-0002-7814-5424"
    },
    {
      "affs": [
        0
      ],
      "name": "Luca Scalise"
    },
    {
      "affs": [
        0
      ],
      "name": "Antonio Mosca"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Laura De Fazio",
      "orcid": "0009-0004-9280-2023"
    },
    {
      "affs": [
        0
      ],
      "name": "Martina Costa"
    },
    {
      "affs": [
        1
      ],
      "name": "Matteo Molica",
      "orcid": "0000-0001-6391-4406"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Marco Rossi",
      "orcid": "0000-0002-7258-475X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/exk09nth7za9s.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18213573",
  "fulltext_url": null,
  "id": "exk09nth7za9s",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/21/3573",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/exk09nth7za9s.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:40Z",
      "native_id": "10.3390/cancers18213573",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/21/3573"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6694",
      "subfield": "oncology"
    }
  ],
  "title": "Achievement and Persistence of MRD Negativity with Anti-CD38-Based Regimens in Newly Diagnosed Multiple Myeloma: A Systematic Review and Network Meta-Analysis",
  "title_text": "Achievement and Persistence of MRD Negativity with Anti-CD38-Based Regimens in Newly Diagnosed Multiple Myeloma: A Systematic Review and Network Meta-Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:40Z",
  "url": "https://research.draconitic.com/paper/exk09nth7za9s",
  "venue": "Cancers",
  "versions": []
}