{
  "abstract": "Lung-cancer cell-cycle progression is shaped by interacting checkpoint, transcriptional, chromatin, and non-coding RNA regulatory layers rather than by isolated molecular alterations. This integrative review uses SMARCB1, NOC2L, CDCA4, and CHEK1 as four complementary anchor regulators representing SWI/SNF-dependent chromatin remodeling, inhibition of histone acetyltransferase activity, E2F-linked transcriptional modulation, and checkpoint signaling, respectively. We critically map their literature-supported relationships across G1, S, G2, and M and integrate DNA and histone methylation, acetylation, chromatin remodeling, phosphorylation, ubiquitination, hydroxylation, and non-coding RNA regulation. Importantly, lung-cancer-specific evidence is distinguished from evidence extrapolated from other tumor models, and experimentally established mechanisms are separated from contextual or hypothesis-generating phase assignments. The strongest lung-specific evidence concerns CHEK1 dependence, replication stress, and chromatin-state plasticity, whereas several proposed phase-specific functions of NOC2L, CDCA4, and SMARCB1 remain incompletely validated in lung cancer. Recent 2026 studies further emphasize subtype-specific CHEK1 biology, therapy-associated chromatin reprogramming, and long non-coding RNA control. This framework identifies testable regulatory hypotheses while avoiding interpretation of network association as direct causality.",
  "abstract_shown": true,
  "affiliations": [
    "Semillero de Investigación—Biología Molecular del Cáncer, Facultad de Medicina, Fundación Universitaria Sanitas, Bogotá 110131, Colombia",
    "Dirección Académica, Universidad Nacional de Colombia, Sede de La Paz, La Paz 111016, Colombia",
    "Grupo de Investigación INPAC, Specialized Laboratory, Clinica Universitaria Colombia, Clínica Colsanitas S.A., Bogotá 111321, Colombia",
    "Grupo de Investigación INPAC, Department of Internal Medicine, Clinica Universitaria Colombia, Clínica Colsanitas S.A., Bogotá 111321, Colombia",
    "Grupo de Investigación INPAC, Facultad de Medicina, Fundación Universitaria Sanitas, Bogotá 110131, Colombia",
    "Grupo de Investigación INPAC, Unidad de Investigación, Fundación Universitaria Sanitas, Bogotá 110131, Colombia",
    "Infectious Diseases Department, Clinica Universitaria Colombia, Clínica Colsanitas S.A., Bogotá 111321, Colombia",
    "Keralty, Sanitas International Organization, Grupo de Investigación INPAC, Fundación Universitaria Sanitas, Bogotá 110131, Colombia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Isabella Salcedo-Tuiran",
      "orcid": "0009-0004-1968-9650"
    },
    {
      "affs": [
        1
      ],
      "name": "César Payán-Gómez",
      "orcid": "0000-0002-0633-1332"
    },
    {
      "affs": [
        2
      ],
      "name": "Juan Javier López-Rivera",
      "orcid": "0000-0003-4989-4853"
    },
    {
      "affs": [
        3
      ],
      "name": "Luisa Fernanda Patiño-Unibio"
    },
    {
      "affs": [
        4
      ],
      "name": "Sally Lorena Arboleda-Mojica"
    },
    {
      "affs": [
        5
      ],
      "name": "Claudia Aristizábal-Guzmán"
    },
    {
      "affs": [
        6
      ],
      "name": "Carlos Arturo Álvarez-Moreno",
      "orcid": "0000-0001-5419-4494"
    },
    {
      "affs": [
        7
      ],
      "name": "Mario Arturo Isaza-Ruget"
    },
    {
      "affs": [
        5
      ],
      "name": "Beatriz Andrea Otálora-Otálora",
      "orcid": "0000-0002-5668-0266"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ey41921e7abxr.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219992",
  "fulltext_url": null,
  "id": "ey41921e7abxr",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9992",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-07",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/ey41921e7abxr.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:27Z",
      "native_id": "10.3390/ijms27219992",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9992"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Mapping the Epigenetic Regulatory Landscape and Core Transcriptional Axes Across Cell Cycle Phases in Lung Cancer",
  "title_text": "Mapping the Epigenetic Regulatory Landscape and Core Transcriptional Axes Across Cell Cycle Phases in Lung Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:27Z",
  "url": "https://research.draconitic.com/paper/ey41921e7abxr",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}