{
  "abstract": "The present study aims to explore the phenotypic variability of the inflammatory response to a lipopolysaccharide (LPS) challenge in goats and compare the reaction between two lines divergently selected for functional longevity. Hyper-selection based on functional longevity successfully created two groups of goats with different lifespans (High_LGV and Low_LGV). Primiparous goats were injected intravenously with LPS to trigger an inflammatory response, with a total of 83 goats, including 42 High_LGV and 41 Low_LGV goats. Blood was sampled 12 times at −72, 0 (injection), 2, 4, 6, 8, 10, 12, 24, 48, 72, and 144 hours. Baseline cytokine concentrations (average of hours −72 and 0) showed no significant differences between longevity lines for any of the 14 measured cytokines. Among the six cytokines that responded to the LPS challenge (IFN-γ, IL4, IL-6, IL-10, MIP1α, and TNFα), three showed significant differences between longevity lines in their temporal response profiles. Low_LGV goats exhibited stronger acute inflammatory responses with greater IL-6 and IFN-γ concentrations during the early hours post-challenge, while High_LGV goats showed elevated MIP1α concentrations during the resolution phase. In parallel, whole blood was stimulated for 24 hours with LPS on a total of 157 goats for ex vivo assessment of the blood response. The IL-6 concentration measured in the whole blood assay showed a moderate correlation with the in vivo response and revealed no difference between the longevity lines. These results suggest that a stronger acute inflammatory response, characterised by elevated pro-inflammatory cytokine production, may be detrimental to functional longevity in dairy goats, possibly through increased tissue damage and impaired recovery following inflammatory challenges.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Marie Ithurbide"
    },
    {
      "name": "Rachel Rupp"
    },
    {
      "name": "Thierry Fassier"
    },
    {
      "name": "Nicolas N.C. Friggens"
    },
    {
      "name": "Gilles Foucras"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ey9q48typ4d40.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0356779",
  "fulltext_url": null,
  "id": "ey9q48typ4d40",
  "issns": [
    "1932-6203",
    "1932-6203"
  ],
  "landing_url": "https://hal.inrae.fr/hal-05746430v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.sa"
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    [
      "openalex",
      "1311|Genetic and phenotypic traits in livestock"
    ]
  ],
  "openalex": "W7204541789",
  "pdf_url": "https://hal.inrae.fr/hal-05746430/document",
  "pmcid": null,
  "pmid": "42664276",
  "published": "2026-08-28",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/ey9q48typ4d40.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "hal-05746430",
      "source": "hal",
      "url": "https://hal.inrae.fr/hal-05746430v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetic and phenotypic traits in livestock",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Effect of longevity genotype on acute phase response to a lipopolysaccharide challenge in dairy goats",
  "title_text": "Effect of longevity genotype on acute phase response to a lipopolysaccharide challenge in dairy goats",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/ey9q48typ4d40",
  "venue": "PLoS ONE",
  "versions": []
}