{
  "abstract": "The prevalence of obesity has risen sharply in recent years, prompting the need for safer and more biocompatible therapeutic alternatives to conventional anti-obesity drugs. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized using pomegranate husk extract via two green approaches: conventional heating and microwave-assisted synthesis. Structural and morphological characterizations confirmed successful nanoparticle formation. Microwave-assisted ZnO nanoparticles (MA-ZnO NPs) exhibited smaller particle dimensions and narrower polydispersity compared with conventionally synthesized ZnO NPs. Both types of ZnO NPs demonstrated notable antioxidant activity (>62% scavenging in DPPH and ABTS assays) and strong inhibitory effects against pancreatic lipase and α-amylase (>70%), comparable to standard drugs such as orlistat and acarbose. Cytotoxicity assays using Vero cells confirmed high biocompatibility, with >60% cell viability. This work presents a comparative evaluation of two green synthesis methods and highlights the potential of biogenic ZnO NPs as multifunctional agents for oxidative stress reduction and enzyme inhibition in obesity management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR)",
    "Department of Allied Health Sciences, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR)",
    "School of Pharmacy, Jiangsu Medical College",
    "Department of Natural Science, Faculty of Science, BGMEA University of Fashion and Technology (BUFT)",
    "Faculty of Health and Life Sciences, INTI International University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shi-Yan Cheah"
    },
    {
      "affs": [
        0
      ],
      "name": "You-Kang Phang",
      "orcid": "0000-0001-7228-2519"
    },
    {
      "affs": [
        0
      ],
      "name": "Sharon Chia-Yen Lim"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming-Xiu Koh",
      "orcid": "0009-0002-1283-171X"
    },
    {
      "affs": [
        1
      ],
      "name": "Sinouvassane Djearamane",
      "orcid": "0000-0002-8251-662X"
    },
    {
      "affs": [
        1
      ],
      "name": "Hemaroopini Subramaniam",
      "orcid": "0000-0002-4309-644X"
    },
    {
      "affs": [
        0
      ],
      "name": "Boon Hoe Lim",
      "orcid": "0000-0002-7715-1531"
    },
    {
      "affs": [
        2
      ],
      "name": "Fang Li"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Mohammod Aminuzzaman",
      "orcid": "0000-0002-5842-1460"
    },
    {
      "affs": [
        4
      ],
      "name": "Ling Shing Wong",
      "orcid": "0000-0002-5869-0804"
    },
    {
      "affs": [
        0
      ],
      "name": "Lai‐Hock Tey",
      "orcid": "0000-0001-8669-1479"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyadnh2cqp0b7.bib",
  "cited_by": 15,
  "doi": "10.1080/21691401.2026.2668258",
  "fulltext_url": null,
  "id": "eyadnh2cqp0b7",
  "issns": [
    "2169-1401",
    "2169-141X"
  ],
  "landing_url": "https://doi.org/10.1080/21691401.2026.2668258",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Nanoparticles: synthesis and applications"
    ]
  ],
  "openalex": "W7161410683",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/21691401.2026.2668258?needAccess=true",
  "pmcid": null,
  "pmid": "42142531",
  "published": "2026-05-16",
  "publisher": "Informa",
  "ris": "https://research.draconitic.com/paper/eyadnh2cqp0b7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:27:00Z",
      "native_id": "W7161410683",
      "source": "openalex",
      "url": "https://doi.org/10.1080/21691401.2026.2668258"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Nanoparticles: synthesis and applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Green synthesis of ZnO nanoparticles using pomegranate husk extract: comparative evaluation of antioxidant, enzyme inhibition, and cytotoxic properties",
  "title_text": "Green synthesis of ZnO nanoparticles using pomegranate husk extract: comparative evaluation of antioxidant, enzyme inhibition, and cytotoxic properties",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T13:21:06Z",
  "url": "https://research.draconitic.com/paper/eyadnh2cqp0b7",
  "venue": "Artificial Cells Nanomedicine and Biotechnology",
  "versions": []
}