{
  "abstract": "Background/objectives\n\nWe compared next-morning fecal metabolic and microbial responses to five acute fueling strategies.Methods\n\nEight male recreational rowers with complete specimens from 12 crossover completers received an erythritol comparator, two carbohydrate doses, fixed carbohydrate-protein, and personalized carbohydrate-protein (P-CPS). Eighty specimens yielded 40 paired changes. Participant-blocked, period-adjusted models used restricted permutations and Benjamini-Hochberg false discovery rate (FDR) correction.Results\n\nNo primary global test passed across-modality FDR correction: SCFAs, p = 0.0321, q = 0.0963; metabolome, q = 0.1334; microbiome, q = 0.2813. No metabolite or originally annotated genus passed its omnibus FDR family. Post hoc SILVA 138.2 reclassification retained a nonsignificant global result but identified three low-count genus-level omnibus signals. Secondary change-score contrasts indicated higher isovaleric and isobutyric post/pre fold changes under P-CPS, fixed carbohydrate-protein, and high carbohydrate than under the comparator. However, no concentration or composite-endpoint contrast remained FDR-positive in post hoc models adjusting for same-trial pre-trial values. Caproic acid evidence also weakened with expanded correction and analytical-range checks. Two metabolome-SCFA principal-component correlations survived FDR correction and persisted after exclusion of overlapping annotations.Conclusions\n\nThis pilot identified model-sensitive secondary chemical signals without FDR-supported global intervention effects. Baseline imbalance, unmeasured beverage osmolality and fecal water, and quantification limitations preclude attributing these signals to increased fermentation or nutritional benefit.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physical Education, Capital Normal University, Beijing 100048, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiangyu Wang",
      "orcid": "0000-0002-9436-6630"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyb4j4gsezsf5.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16100718",
  "fulltext_url": "https://europepmc.org/articles/PMC13707109",
  "id": "eyb4j4gsezsf5",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://europepmc.org/article/MED/42941194",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7214603303",
  "pdf_url": "https://europepmc.org/articles/PMC13707109?pdf=render",
  "pmcid": "PMC13707109",
  "pmid": "42941194",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eyb4j4gsezsf5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42941194",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42941194"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Fecal Metabolic and Microbial Responses to Five Acute Fueling Strategies During a 60-Minute Rowing Protocol: A Randomized Crossover Multi-Omics Pilot Study.",
  "title_text": "Fecal Metabolic and Microbial Responses to Five Acute Fueling Strategies During a 60-Minute Rowing Protocol: A Randomized Crossover Multi-Omics Pilot Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/eyb4j4gsezsf5",
  "venue": "Metabolites",
  "versions": []
}