{
  "abstract": "Background: Possible Sarcopenic obesity (PSO) carries higher risks than either condition alone, but whether its risk factors differ by sex and age remains unclear. We investigated the prevalence, risk factors, and sex/age differences of PSO using traditional regression, Bayesian analysis, and machine learning.\n\nMethods: This cross-sectional study included 427 community-dwelling adults aged 60–98 years. PSO was defined as concurrent possible sarcopenia (AWGS 2019: low handgrip strength + slow gait speed) and central obesity (waist circumference ≥ 90 cm in men, ≥ 85 cm in women). Multivariable logistic regression, sex- and age-stratified analyses, dose–response analysis, mediation analysis, and E-value sensitivity analysis were performed. Bayesian hierarchical models and XGBoost with SHAP were used for validation.\n\nResults: PSO prevalence was 8.7% (37/427). Overall, age (OR = 1.12, 95%CI:1.05–1.19) was a risk factor and hemoglobin (OR = 0.97, 95%CI:0.94–0.99) was protective. Sex-stratified analysis revealed marked differences: in men, BMI was a strong risk factor (OR = 1.54, 95%CI:1.19–2.01); in women, low hemoglobin (OR = 0.96, 95%CI:0.92–0.99) and high white blood cell count (OR = 1.43, 95%CI:1.04–1.98) were significant. Age-stratified analysis showed that in those < 75 years, glucose (OR = 1.26) and white blood cell count (OR = 1.23) were important; in those ≥ 75 years, BMI showed a strong effect (OR = 1.91, 95%CI:1.33–2.76). Bayesian analysis produced consistent findings with narrow credible intervals. The XGBoost model achieved good discrimination (AUC = 0.86), with SHAP confirming age, BMI, and hemoglobin as top predictors. Dose–response analysis showed a linear relationship between hemoglobin and PSO (p for nonlinearity = 0.743). E-value analysis confirmed robustness to unmeasured confounding (E-values ≥ 1.47).\n\nConclusions: Risk factors for PSO differ substantially by sex and age. These findings support targeted prevention strategies: weight control in men, nutritional and inflammatory monitoring in women, metabolic management in younger-old adults, and weight control in the oldest-old.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12877-026-08088-0.",
  "abstract_shown": true,
  "affiliations": [
    "Geriatric Medicine Department, The Second People’s Hospital of Nanning, Guangxi, China",
    "Department of Respiratory and Critical Care Medicine, Guangxi Jiangbin Hospital, Nanning, Guangxi China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cong Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuhai Dang",
      "orcid": "0009-0002-1334-3486"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyckgd4p1kxyx.bib",
  "cited_by": 0,
  "doi": "10.1186/s12877-026-08088-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729344/",
  "id": "eyckgd4p1kxyx",
  "issns": [
    "1471-2318"
  ],
  "landing_url": "https://doi.org/10.1186/s12877-026-08088-0",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2737|Nutrition and Health in Aging"
    ]
  ],
  "openalex": "W7196976900",
  "pdf_url": null,
  "pmcid": "PMC13729344",
  "pmid": "42977923",
  "published": "2026-08-06",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/eyckgd4p1kxyx.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:07Z",
      "native_id": "PMC13729344",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12877-026-08088-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Nutrition and Health in Aging",
      "subfield": "physiology"
    }
  ],
  "title": "Sex- and age-specific risk factors for possible sarcopenic obesity in community-dwelling older adults: a cross-sectional study",
  "title_text": "Sex- and age-specific risk factors for possible sarcopenic obesity in community-dwelling older adults: a cross-sectional study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:07Z",
  "url": "https://research.draconitic.com/paper/eyckgd4p1kxyx",
  "venue": "BMC Geriatrics",
  "versions": []
}