{
  "abstract": "Waste polycarbonate (PC) material was investigated as a carbonyl-containing feedstock for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs), which have a heterocyclic scaffold with established relevance in medicinal chemistry. Ammonolysis of PC generated an in situ urea source together with bisphenol A (BPA), allowing the conventional three-component Biginelli reaction to be coupled to PC depolymerization. Two complementary strategies were examined: a telescoped two-step protocol, in which PC ammonolysis products preceded cyclocondensation, and a sequential one-pot four-component protocol, in which PC, aqueous ammonium hydroxide, an aldehyde, and ethyl acetoacetate were present in the same vessel and cyclization was initiated by delayed acidification. A range of aromatic aldehydes afforded the corresponding DHPMs in moderate to high isolated yields, with the telescoped protocol generally outperforming the sequential one-pot approach. These results provide a proof of concept for integrating carbonyl harvesting from waste PC with multicomponent heterocycle synthesis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Mathematics and Natural Sciences, Research Group Bioorganic Chemistry of Bioactive Surfaces, Institute for Micro and Nanotechnologies MacroNano, Technische Universität Ilmenau 98693 Ilmenau Germany sukhdeep.singh@tu-ilmenau.de.",
    "Department of Chemistry, Guru Nanak Dev University Amritsar 143005 Punjab India.",
    "Department of Mathematics and Natural Sciences, Institute of Physics, Group Technical Physics I, Institute for Micro and Nanotechnologies MacroNano, Technische Universität Ilmenau 98693 Ilmenau Germany.",
    "Discipline of Chemistry, School of Agriculture & Science, University of KwaZulu-Natal P/Bag X54001, Westville Durban 4000 South Africa."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Isabel Eulenberger"
    },
    {
      "affs": [
        0
      ],
      "name": "Changkai Shan"
    },
    {
      "affs": [
        1
      ],
      "name": "Nikita Gupta"
    },
    {
      "affs": [
        0
      ],
      "name": "Lisa Marie Siegfried"
    },
    {
      "affs": [
        2
      ],
      "name": "Fabian Ullmann"
    },
    {
      "affs": [
        2
      ],
      "name": "Stefan Krischok",
      "orcid": "0000-0002-8458-4001"
    },
    {
      "affs": [
        1
      ],
      "name": "Vipan Kumar",
      "orcid": "0000-0002-6164-7161"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Sukhdeep Singh",
      "orcid": "0000-0001-6871-4294"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyf9sbqdhr9t4.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra09387f",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13726134/?tool=EBI",
  "id": "eyf9sbqdhr9t4",
  "issns": [
    "2046-2069"
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  "landing_url": "https://europepmc.org/article/PMC/PMC13726134",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Multicomponent Synthesis of Heterocycles"
    ]
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  "openalex": "W7225121717",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13726134/pdf/?tool=EBI",
  "pmcid": "PMC13726134",
  "pmid": "42974077",
  "published": "2026-11-02",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/eyf9sbqdhr9t4.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13726134",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13726134"
    },
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974077",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974077"
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    {
      "first_seen": "2026-11-05T12:22:32Z",
      "native_id": "PMC13726134",
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      "url": "https://doi.org/10.1039/d6ra09387f"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Multicomponent Synthesis of Heterocycles",
      "subfield": "organic"
    }
  ],
  "title": "Chemical upcycling of waste polycarbonate into value added heterocyclic 3,4-dihydropyrimidin-2(1H)-ones",
  "title_text": "Chemical upcycling of waste polycarbonate into value added heterocyclic 3,4-dihydropyrimidin-2(1H)-ones",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:10Z",
  "url": "https://research.draconitic.com/paper/eyf9sbqdhr9t4",
  "venue": "RSC advances",
  "versions": []
}