{
  "abstract": "Objective\n\nThis study investigated whether fiberoptic endoscopic evaluation of swallowing (FEES)-derived parameters reflect patient-reported dysphagia and swallowing-related quality of life in patients with oropharyngeal squamous cell carcinoma (OPSCC) after surgery-based multimodal therapy with free-flap reconstruction. In addition, it assessed the roles of psychological distress and xerostomia in this context.Methods\n\nThis multicenter, cross-sectional exploratory study included 50 patients. FEES parameters comprised Penetration-Aspiration Scale (PAS) and residue scores. Patient-reported outcomes were assessed using the Sydney Swallow Questionnaire (SSQ) and MD Anderson Dysphagia Inventory (MDADI), psychological distress using the Hospital Anxiety and Depression Scale (HADS), and xerostomia using the Xerostomia Inventory (XI). Associations were examined using Spearman correlations with Benjamini-Hochberg correction and exploratory rank-transformed multiple linear regression.Results\n\nFEES parameters showed no significant bivariate associations with SSQ or MDADI total scores after correction. HADS and XI showed moderate to strong bivariate associations with SSQ and MDADI. In exploratory multivariable analyses, HADS (β = 0.372, p = 0.012) and PAS max (β = 0.318, p = 0.006) were independently associated with SSQ, whereas XI was not (β = 0.268, p = 0.065). HADS (β = -0.339, p = 0.008), XI (β = -0.433, p < 0.001), and PAS max (β = -0.301, p = 0.003) were independently associated with MDADI.Conclusion\n\nThe FEES-derived parameters only partially reflected patient-reported swallowing impairment. These findings support a multidimensional understanding of post-therapeutic dysphagia and suggest routine integration of psychosocial and symptom-oriented assessments into follow-up care in this specific patient population.Level of evidence\n\n4.Trial registration\n\nGerman Clinical Trials Register (DRKS) Registration Number: DRKS00038870.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology, Head and Neck Surgery, Catholic Hospital Hagen University of Witten/Herdecke Hagen Germany.",
    "Department of Otorhinolaryngology, Head and Neck Surgery Hospitals of the City of Cologne Cologne Germany.",
    "Department of Otorhinolaryngology, Head and Neck Surgery, St. Elisabeth-Hospital Ruhr University Bochum Bochum Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Inga Marte Charlott Seuthe",
      "orcid": "0000-0002-0295-5447"
    },
    {
      "affs": [
        0
      ],
      "name": "Julius Friedrich Ennenbach",
      "orcid": "0009-0007-5319-4098"
    },
    {
      "affs": [
        0
      ],
      "name": "Natalja Bolotina",
      "orcid": "0009-0001-1267-2790"
    },
    {
      "affs": [
        1
      ],
      "name": "Nermin Rüdiger",
      "orcid": "0009-0001-5548-2604"
    },
    {
      "affs": [
        0
      ],
      "name": "Sabine Eichhorn",
      "orcid": "0000-0001-7877-7977"
    },
    {
      "affs": [
        0
      ],
      "name": "Eren Erdogan",
      "orcid": "0000-0002-2456-2169"
    },
    {
      "affs": [
        2
      ],
      "name": "Stijn Bogaert",
      "orcid": "0000-0003-3575-6775"
    },
    {
      "affs": [
        2
      ],
      "name": "Stefan Dazert",
      "orcid": "0000-0002-6240-1390"
    },
    {
      "affs": [
        1
      ],
      "name": "Steffen Maune",
      "orcid": "0000-0002-0858-8705"
    },
    {
      "affs": [
        0
      ],
      "name": "Jonas Jae-Hyun Park",
      "orcid": "0000-0002-4582-819X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyjsapz560vyj.bib",
  "cited_by": 0,
  "doi": "10.1002/lio2.70617",
  "fulltext_url": "https://europepmc.org/articles/PMC13683555",
  "id": "eyjsapz560vyj",
  "issns": [
    "2378-8038"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908754",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RD1-811"
    ],
    [
      "lcc",
      "RF1-547"
    ],
    [
      "openalex",
      "3616|Dysphagia Assessment and Management"
    ]
  ],
  "openalex": "W7223054595",
  "pdf_url": "https://europepmc.org/articles/PMC13683555?pdf=render",
  "pmcid": "PMC13683555",
  "pmid": "42908754",
  "published": "2026-10-20",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/eyjsapz560vyj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42908754",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908754"
    },
    {
      "first_seen": "2026-10-31T14:22:14Z",
      "native_id": "0d68aff6851449afbb2da25968f97950",
      "source": "doaj",
      "url": "https://doi.org/10.1002/lio2.70617"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RD1-811",
      "subfield": "surgery"
    }
  ],
  "title": "Patient-Reported Dysphagia After Multimodal Therapy and Radial Forearm Free-Flap Reconstruction for OPSCC: Associations With FEES Findings, Psychological Distress, and Xerostomia.",
  "title_text": "Patient-Reported Dysphagia After Multimodal Therapy and Radial Forearm Free-Flap Reconstruction for OPSCC: Associations With FEES Findings, Psychological Distress, and Xerostomia.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:14Z",
  "url": "https://research.draconitic.com/paper/eyjsapz560vyj",
  "venue": "Laryngoscope investigative otolaryngology",
  "versions": []
}