{
  "abstract": "Background\n\nFractional flow reserve (FFR)-guided coronary artery bypass grafting (CABG) may reduce unnecessary grafts and improve outcomes. However, in the FARGO (Fractional Flow Reserve vs Angiography Randomization for Graft Optimization) trial, FFR was reduced significantly after 6 months in deferred lesions.Objectives\n\nThe purpose of this study was to evaluate long-term clinical outcomes after FFR-guided CABG compared to angiography-guided CABG.Methods\n\nIn this multicenter randomized clinical trial, 100 patients were randomized to FFR-guided (n = 50) or angiography-guided CABG (n = 50). Patients underwent a 6-month follow-up coronary angiography with FFR in deferred lesions. In this extended long-term follow-up revascularization, myocardial infarction, stroke, death, and major adverse cardiac and cerebrovascular events (MACCE), a composite of the individual endpoints, were assessed.Results\n\nAfter a median follow-up of 8.8 years (IQR: 8.3, 9.3), patients in the FFR-guided group had significantly more MACCE compared to the angiography-guided group, (26 [52%] vs 16 [32%], log-rank test P = 0.03). This difference was driven by significantly more long-term revascularization, FFR-guided CABG 32% vs angiography-guided 12%, log-rank test P = 0.01. The revascularization rate was significantly higher from 0 to 1 year (12 [24%] vs 3 [6%], log-rank test P = 0.01), whereas beyond 1 year, rates were similar (4 [8%] vs 3 [6%], log-rank test P = 0.47). Most patients had stable symptoms, and revascularization was symptom-driven. Myocardial infarction (6 [12%] vs 3 [6%]), death (10 [20%] vs 7 [14%]), and stroke (6 [12%] vs 6 [12%]) did not differ significantly between the groups.Conclusions\n\nFFR-guided CABG was associated with a significantly higher rate of MACCE after CABG, driven by more revascularization within the first year.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Odense University Hospital, Odense, Denmark. Electronic address: jens.troan3@rsyd.dk.",
    "Department of Cardiothoracic Surgery, Odense University Hospital, Odense, Denmark.",
    "Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.",
    "Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.",
    "Department of Cardiology, Zealand University Hospital, Roskilde, Denmark.",
    "Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.",
    "Department of Cardiothoracic Surgery, Aalborg University Hospital, Aalborg, Denmark.",
    "Department of Cardiology, Odense University Hospital, Odense, Denmark; DaCHE, Department of Public Health, University of Southern Denmark, Odense, Denmark.",
    "Department of Cardiology, Odense University Hospital, Odense, Denmark.",
    "Department of Medicine, Stanford University, Stanford, California, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA; VA Palo Alto Health Care System, Palo Alto, California, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jens Trøan",
      "orcid": "0000-0002-0929-8697"
    },
    {
      "affs": [
        1
      ],
      "name": "Anne Langhoff Thuesen"
    },
    {
      "affs": [
        2
      ],
      "name": "Evald Høj Christiansen"
    },
    {
      "affs": [
        3
      ],
      "name": "Ashkan Eftekhari",
      "orcid": "0000-0003-2871-8279"
    },
    {
      "affs": [
        4
      ],
      "name": "Ole Havndrup"
    },
    {
      "affs": [
        5
      ],
      "name": "Ivy Susanne Modrau",
      "orcid": "0000-0002-2812-6591"
    },
    {
      "affs": [
        1
      ],
      "name": "Lars Peter Riber"
    },
    {
      "affs": [
        6
      ],
      "name": "Jan Jesper Andreasen"
    },
    {
      "affs": [
        3
      ],
      "name": "Svend Eggert Jensen"
    },
    {
      "affs": [
        7
      ],
      "name": "Joachim Dahl Steensbjerre"
    },
    {
      "affs": [
        3
      ],
      "name": "Julie Juul Siig"
    },
    {
      "affs": [
        4
      ],
      "name": "Yusuf Abdi Isse"
    },
    {
      "affs": [
        8
      ],
      "name": "Anders Junker"
    },
    {
      "affs": [
        1
      ],
      "name": "Poul Erik Mortensen"
    },
    {
      "affs": [
        9
      ],
      "name": "William F Fearon"
    },
    {
      "affs": [
        8
      ],
      "name": "Lisette Okkels Jensen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyk14kn88x1r4.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacadv.2026.103332",
  "fulltext_url": "https://europepmc.org/articles/PMC13685978",
  "id": "eyk14kn88x1r4",
  "issns": [
    "2772-963X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42868963",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Cardiac and Coronary Surgery Techniques"
    ]
  ],
  "openalex": "W7213976547",
  "pdf_url": "https://europepmc.org/articles/PMC13685978?pdf=render",
  "pmcid": "PMC13685978",
  "pmid": "42868963",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eyk14kn88x1r4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42868963",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42868963"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cardiac and Coronary Surgery Techniques",
      "subfield": "surgery"
    }
  ],
  "title": "Long-Term Clinical Outcomes After Physiology-Guided vs Angiography-Guided Coronary Artery Bypass Grafting: From the FARGO Trial.",
  "title_text": "Long-Term Clinical Outcomes After Physiology-Guided vs Angiography-Guided Coronary Artery Bypass Grafting: From the FARGO Trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/eyk14kn88x1r4",
  "venue": "JACC. Advances",
  "versions": []
}