{
  "abstract": "Background/purpose\n\nLight-emitting diode-based photobiomodulation (LED PBM) potentially reduces pain and root resorption risk in orthodontics. This study evaluated 850-nm LED PBM effects on pain and dentin sialoprotein (DSP) levels during canine distalization.Materials and methods\n\nThis single-blind, parallel-group randomized controlled trial included 16 orthodontic patients (8 per group). Participants were randomly allocated in a 1:1 ratio to either an active LED group or a sham control group. Pain intensity was assessed using a visual analog scale (VAS) at 0, 24, and 48 h following canine distalization at four consecutive monthly visits (T₁-T₄) and expressed as the area under the curve (AUC0-48h). DSP concentrations in gingival crevicular fluid were measured at pretreatment (T₀), initiation of distalization (T₁), and follow-up visits (T₂, T₃) using sandwich ELISA. Longitudinal changes were analyzed using linear mixed-effects models.Results\n\nThe LED group demonstrated a significantly lower pain intensity compared with the control group, with a significant group-by-time interaction (χ²=9.46, P=0.024). Adjusted mean values of AUC0-48h were significantly reduced in the LED group at T₃ and T₄, with the greatest difference observed at T₃ (P < 0.001). A significant group-by-time interaction was observed for DSP (χ² = 9.75, P = 0.021), with lower DSP levels in the LED group being reported at T₁, T₂, and T₃ compared with the control group (P < 0.05).Conclusion\n\nRepeated 850-nm LED PBM was associated with reduced cumulative pain and attenuated DSP increases during canine distalization, suggesting potential benefits for patient comfort and root resorption-related responses.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.",
    "Faculty of Dentistry, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.",
    "Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Thanh Thuy-Nhat Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Anh Ho-Quynh Nguyen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hung Trong Hoang"
    },
    {
      "affs": [
        0
      ],
      "name": "Tham Dong Khac"
    },
    {
      "affs": [
        0
      ],
      "name": "Phuc Hoai Le"
    },
    {
      "affs": [
        2
      ],
      "name": "H K Tu Trinh"
    },
    {
      "affs": [
        2
      ],
      "name": "Kieu-Minh Le"
    },
    {
      "affs": [
        2
      ],
      "name": "Diem Truong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyqgny32q55eg.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jds.2025.07.3502",
  "fulltext_url": "https://europepmc.org/articles/PMC13689599",
  "id": "eyqgny32q55eg",
  "issns": [
    "1991-7902",
    "2213-8862"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923675",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Laser Applications in Dentistry and Medicine"
    ]
  ],
  "openalex": "W7223565311",
  "pdf_url": "https://europepmc.org/articles/PMC13689599?pdf=render",
  "pmcid": "PMC13689599",
  "pmid": "42923675",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eyqgny32q55eg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923675",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923675"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Laser Applications in Dentistry and Medicine",
      "subfield": "imaging"
    }
  ],
  "title": "Effects of 850-nm light-emitting diode photobiomodulation on pain intensity and dentin sialoprotein levels during canine distalization: A randomized controlled trial.",
  "title_text": "Effects of 850-nm light-emitting diode photobiomodulation on pain intensity and dentin sialoprotein levels during canine distalization: A randomized controlled trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/eyqgny32q55eg",
  "venue": "Journal of dental sciences",
  "versions": []
}