{
  "abstract": "Background and aims: In cardiovascular-kidney-metabolic (CKM) syndrome, metabolic dysfunction-associated steatotic liver disease (MASLD) is not included in its staging criteria. We aimed to evaluate the associations between vibration-controlled transient elastography (VCTE)-derived liver parameters and advanced CKM stages, and to examine whether the CKM profile differs among MASLD subtypes.\n\nMethods: VCTE and cardio-metabolic assessments were conducted among individuals enrolled in the New Hong Kong Cardiovascular Risk Factor Prevalence Study (NCRISPS), an ongoing population-based cohort recruiting Chinese residents of Hong Kong SAR between 2019 and 2024.\n\nResults: Among 3199 eligible participants, 37.2% had MASLD, with 34.4% having MASLD alone and 2.8% due to combined etiology. VCTE-derived controlled attenuation parameter (CAP), liver stiffness (LS), and FibroScan-AST (FAST) score each showed graded associations with advanced CKM stages (all P<0.05). Compared to participants without steatotic liver disease, those with MASLD alone (adjusted OR 1.44, 95% CI 1.07–1.94; P = 0.016) and MASLD due to combined etiology (adjusted OR 2.35, 95% CI 1.22–4.49; P = 0.010) were both associated with significantly higher odds of advanced CKM stages.\n\nConclusions: MASLD, with and without combined etiology, was associated with the presence of advanced CKM syndrome. VCTE-derived parameters including CAP, LS, and FAST score were all associated with advanced CKM stages in a graded manner and whether inclusion of these non-invasive markers improves CKM syndrome staging and classification warrants longitudinal evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong",
    "State Key Laboratory of Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong",
    "Department of Medicine and Therapeutics, The Chinese University of Hong Kong",
    "School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lanlan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "David Tak-Wai Lui"
    },
    {
      "affs": [
        0
      ],
      "name": "Carol Ho-Yi Fong"
    },
    {
      "affs": [
        0
      ],
      "name": "Lung-Yi Mak"
    },
    {
      "affs": [
        0
      ],
      "name": "Chloe Yu-Yan Cheung"
    },
    {
      "affs": [
        0
      ],
      "name": "Jimmy Ho-Cheung Mak"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Aimin Xu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jean Woo"
    },
    {
      "affs": [
        0
      ],
      "name": "Kathryn Choon-Beng Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Hung-Fat Tse"
    },
    {
      "affs": [
        3
      ],
      "name": "Tai-Hing Lam"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu-Cho Woo"
    },
    {
      "affs": [
        0
      ],
      "name": "Bernard Man-Yung Cheung"
    },
    {
      "affs": [
        0
      ],
      "name": "Man-Fung Yuen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Karen Siu-Ling Lam"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chi-Ho Lee"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyr58xkaqsa0g.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1984746",
  "fulltext_url": null,
  "id": "eyr58xkaqsa0g",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1984746/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/eyr58xkaqsa0g.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:42Z",
      "native_id": "10.3389/fendo.2026.1984746",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1984746/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2392",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Association of VCTE-derived liver parameters and MASLD subtypes with advanced cardiovascular-kidney-metabolic syndrome",
  "title_text": "Association of VCTE-derived liver parameters and MASLD subtypes with advanced cardiovascular-kidney-metabolic syndrome",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:44Z",
  "url": "https://research.draconitic.com/paper/eyr58xkaqsa0g",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}