{ "abstract": "Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems. Driven by advances in mass spectrometry, chromatography and computational analysis, lipidomics has enabled the high-resolution mapping of lipid networks and their functional dynamics across molecular, cellular and organismal scales. In biomedical research, lipidomics is emerging as a powerful platform for biomarker discovery, enabling early diagnosis, prognosis, and therapeutic monitoring of cancer, metabolic, and neurodegenerative diseases. The field is also reshaping drug discovery by uncovering lipid-mediated pathways, identifying novel therapeutic targets, and refining assessments of drug efficacy and safety. Beyond medicine, lipidomic analyses are redefining food and nutrition science by elucidating how dietary lipids influence metabolic health and disease risk. In parallel, environmental and ecological lipidomics are emerging as powerful frameworks for assessing ecosystem health, tracking the impact of pollutants and exploring the biological consequences of climate change. Such approaches are also informing the discovery of sustainable lipid resources and the development of novel biotechnological and agricultural innovations. With its rapidly expanding analytical repertoire and cross-disciplinary relevance, lipidomics is poised to make substantial contributions to both fundamental biology and applied science. This Perspective aims to synthesise the current state of the field, delineate major analytical and conceptual challenges, and outline future directions for translating lipidomic knowledge into tangible societal and environmental benefits.", "abstract_shown": true, "affiliations": [ "Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Dresden, Germany. maria.fedorova@tu-dresden.de", "Singapore Lipidomics Incubator, Singapore, Singapore", "MetaboHUB-MetaTou, Toulouse, France", "West Coast Metabolomics Center, University of California-Davis, Davis, CA, USA", "Medical University of Bialystok, Bialystok, Poland", "University of Perugia, Perugia, Italy", "Department of Dermatology, CDL SKINMAGINE, Medical University of Vienna, Vienna, Austria", "Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark", "Nanyang Technological University, Singapore, Singapore", "The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA", "University of Pardubice, Pardubice, Czech Republic", "Health Research Institute La Fe (IIS La Fe), Valencia, Spain", "Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Melbourne, VIC, Australia", "Baker Heart and Diabetes Institute, Melbourne, VIC, Australia", "Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Dresden, Germany", "Cardiff University, Cardiff, UK", "University of Turku, Turku, Finland", "Åbo Akademi University, Turku, Finland", "Örebro University, Örebro, Sweden", "University of Belgrade, Belgrade, Serbia", "Senckenberg Museum for Natural History Görlitz, Görlitz, Germany", "Leipzig University, Leipzig, Germany", "Maastricht University, Maastricht, Netherlands", "Wageningen University & Research, Wageningen, Netherlands", "Faculty of Medical Sciences, Goce Delcev University, Stip, North Macedonia", "Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany", "Lipotype GmbH, Dresden, Germany", "Aston University & Aston Institute for Membrane Excellence, Birmingham, UK", "Washington State University, Pullman, WA, USA", "Hamad Bin Khalifa University, Doha, Qatar", "Chair of Analytical Food Chemistry, TUM School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, München, Germany", "Metabolomics and Proteomics Core, Helmholtz Zentrum München GmbH, Neuherberg, Germany", "Tsinghua University, Beijing, China", "CESAM- Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Aveiro, Portugal. mrd@ua.pt" ], "article_type": "review", "arxiv": null, "author_total": 31, "authors": [ { "affs": [ 0 ], "name": "Maria Fedorova", "orcid": "0000-0002-4692-3885" }, { "affs": [ 1 ], "name": "Anne K. Bendt", "orcid": "0000-0001-8198-6104" }, { "affs": [ 2 ], "name": "Justine Bertrand‐Michel", "orcid": "0000-0001-9815-1517" }, { "affs": [ 3 ], "name": "Oliver Fiehn", "orcid": "0000-0002-6261-8928" }, { "affs": [ 4 ], "name": "Joanna Godzień", "orcid": "0000-0002-9477-057X" }, { "affs": [ 5 ], "name": "Laura Goracci", "orcid": "0000-0002-9282-9013" }, { "affs": [ 6 ], "name": "Florian Gruber", "orcid": "0000-0003-1094-5641" }, { "affs": [ 7, 8 ], "name": "Xue Li Guan", "orcid": "0000-0002-5189-8178" }, { "affs": [ 9 ], "name": "Xianlin Han", "orcid": "0000-0002-8615-2413" }, { "affs": [ 10 ], "name": "Michal Holčapek", "orcid": "0000-0003-3978-1249" }, { "affs": [ 11 ], "name": "Julia Kuligowski", "orcid": "0000-0001-6979-2235" }, { "affs": [ 12, 13 ], "name": "Peter J. Meikle", "orcid": "0000-0002-2593-4665" }, { "affs": [ 14 ], "name": "Palina Nepachalovich", "orcid": "0000-0002-3404-9537" }, { "affs": [ 15 ], "name": "Valerie B. O’Donnell", "orcid": "0000-0003-4089-8460" }, { "affs": [ 16, 17, 18 ], "name": "Matej Orešič", "orcid": "0000-0002-2856-9165" }, { "affs": [ 14 ], "name": "Sider Penkov", "orcid": "0000-0003-2386-9510" }, { "affs": [ 19 ], "name": "Snježana Petrović", "orcid": "0000-0002-1387-9777" }, { "affs": [ 20 ], "name": "Anton Potapov", "orcid": "0000-0002-4456-1710" }, { "affs": [ 21, 22 ], "name": "Patricia Prabutzki", "orcid": "0009-0002-7472-6843" }, { "affs": [ 23 ], "name": "Laura Righetti", "orcid": "0000-0003-4238-0665" }, { "affs": [ 24 ], "name": "Tatjana Ruskovska", "orcid": "0000-0002-4300-4891" }, { "affs": [ 25 ], "name": "Andrej Shevchenko", "orcid": "0000-0002-5079-1109" }, { "affs": [ 26, 25 ], "name": "Kai Simons", "orcid": "0000-0002-9231-9996" }, { "affs": [ 27 ], "name": "Corinne Michelle Spickett", "orcid": "0000-0003-4054-9279" }, { "affs": [ 26 ], "name": "Olga Vvedenskaya", "orcid": "0000-0002-7828-4328" }, { "affs": [ 28 ], "name": "Jennifer Watts", "orcid": "0000-0003-4349-0639" }, { "affs": [ 29 ], "name": "Markus Rene Wenk", "orcid": "0000-0001-5447-7881" }, { "affs": [ 30, 31 ], "name": "Michael A. Witting", "orcid": "0000-0002-1462-4426" }, { "affs": [ 32 ], "name": "Yu Xia", "orcid": "0000-0001-8694-9900" }, { "affs": [ 16 ], "name": "B.Z. Yang", "orcid": "0000-0001-5561-514X" }, { "affs": [ 33 ], "name": "Maria Rosário Domingues" } ], "bibtex": "https://research.draconitic.com/paper/eys35aekgk2gm.bib", "cited_by": 12, "doi": "10.1038/s41467-026-73797-4", "fulltext_url": null, "id": "eys35aekgk2gm", "issns": [ "2041-1723" ], "landing_url": "https://doi.org/10.1038/s41467-026-73797-4", "language": "en", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "journal", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "1312|Metabolomics and Mass Spectrometry Studies" ] ], "openalex": "W7162666918", "pdf_url": "https://www.nature.com/articles/s41467-026-73797-4.pdf", "pmcid": "PMC13219694", "pmid": "42209482", "published": "2026-05-28", "publisher": "Nature Portfolio", "ris": "https://research.draconitic.com/paper/eys35aekgk2gm.ris", "sources": [ { "first_seen": "2026-10-30T13:26:46Z", "native_id": "W7162666918", "source": "openalex", "url": "https://doi.org/10.1038/s41467-026-73797-4" } ], "subjects": [ { "field": "biochemistry", "origin": "openalex:1312|Metabolomics and Mass Spectrometry Studies", "subfield": "molecular-biology" } ], "title": "A lipidomics roadmap: from basic research to societal challenges", "title_text": "A lipidomics roadmap: from basic research to societal challenges", "type": "peer-reviewed", "updated_at": "2026-11-07T13:20:49Z", "url": "https://research.draconitic.com/paper/eys35aekgk2gm", "venue": "Nature Communications", "versions": [] }