{
  "abstract": "Glucocorticoids regulate the stress response, circadian rhythms, and numerous physiological processes, including cognition, cardiovascular function, metabolism, and immunity. Synthetic glucocorticoids (sGCs), such as methylprednisolone (MPL), are widely prescribed for inflammatory and autoimmune disorders, yet their often severe cognitive side effects remain poorly understood. Here, we examine the impact of chronic MPL treatment on circadian regulation and the synaptic proteome in the perirhinal cortex (PRh) of male rats, a region critical for object recognition memory. We find that corticosteroid signaling in the PRh is subject to circadian modulation across the light–dark cycle, and that MPL disrupts this pattern. MPL alters endogenous circadian and ultradian clock gene expression, and proteomic analyses reveals dysregulation of proteins essential for synaptic transmission and plasticity. Electrophysiological recordings demonstrate impaired synaptic signaling, and behavioral testing shows PRh-dependent novel object recognition deficits. These findings highlight a mechanistic link between sGC treatment, circadian disruption, and cognitive impairment, with broad implications for understanding the cognitive side effects of widely used sGC therapies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Matthew D. B. Claydon",
      "orcid": "0000-0003-3796-6979"
    },
    {
      "name": "Olly Troy",
      "orcid": "0000-0002-1184-110X"
    },
    {
      "name": "Matthew T. Birnie"
    },
    {
      "name": "Yvonne M. Kershaw",
      "orcid": "0000-0001-7318-2050"
    },
    {
      "name": "Gareth R. I. Barker",
      "orcid": "0000-0002-0918-2045"
    },
    {
      "name": "Kate J. Heesom",
      "orcid": "0000-0002-5418-5392"
    },
    {
      "name": "E. Clea Warburton"
    },
    {
      "name": "Zuner. A. Bortolotto",
      "orcid": "0000-0002-5513-8061"
    },
    {
      "name": "Stafford L. Lightman",
      "orcid": "0000-0002-8546-9646"
    },
    {
      "name": "Becky L. Conway-Campbell",
      "orcid": "0000-0002-8494-7431"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eyvr1ke5hvk6e.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11316-3",
  "fulltext_url": null,
  "id": "eyvr1ke5hvk6e",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11316-3",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-07",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/eyvr1ke5hvk6e.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T21:20:59Z",
      "native_id": "10.1038/s42003-026-11316-3",
      "source": "feed-nature",
      "url": "https://www.nature.com/articles/s42003-026-11316-3"
    },
    {
      "first_seen": "2026-11-08T00:20:59Z",
      "native_id": "10.1038/s42003-026-11316-3",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11316-3"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "Corticosteroid treatment dysregulates perirhinal circadian rhythms and synaptic function in rats",
  "title_text": "Corticosteroid treatment dysregulates perirhinal circadian rhythms and synaptic function in rats",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T00:20:25Z",
  "url": "https://research.draconitic.com/paper/eyvr1ke5hvk6e",
  "venue": "Communications Biology",
  "versions": []
}