{
  "abstract": "目的探讨咽喉反流（laryngopharyngeal reflux，LPR）在不同性质声带病变（慢性炎症、良性占位、癌前病变）中的患病率差异，分析LPR对嗓音障碍患者声学功能的影响。方法纳入533例嗓音障碍患者，依据临床诊断分为炎症组（n=222）、良性组（包括息肉、小结、囊肿、任克水肿、肉芽肿，n=250）及癌前组（声带白斑，n=61）。采用反流症状指数量表（reflux symptom index，RSI）和反流体征评分量表（reflux finding score，RFS）评估LPR情况，应用嗓音分析软件检测记录基频（F₀）、基频微扰（jitter）、振幅微扰（shimmer）、最长发声时间（maximum phonation time，MPT）等声学参数及嗓音障碍严重指数（dysphonia severity index，DSI），比较组间及LPR亚组间的差异。结果LPR总患病率50.09%（267/533），在3组间呈显著递增趋势，炎症组36.94%（82/222）、良性组58.00%（145/250）、癌前组65.57%（40/61）（P<0.001）。嗓音声学分析显示，良性组、癌前组的jitter、shimmer显著高于炎症组，而DSI、MPT显著降低（P<0.05）。亚组分析发现，与非LPR相比，良性组、癌前组中LPR阳性者的嗓音损害更严重，两组DSI显著降低，良性组LPR阳性患者jitter、shimmer升高，癌前组LPR阳性患者jitter、shimmer升高，MPT降低，差异具有统计学意义（P<0.05）。结论LPR与声带占位性病变的发生发展密切相关，其患病率随病变性质的进展显著升高。良性占位病变、癌前病变患者表现为明确的嗓音功能叠加损害，LPR是影响嗓音康复预后的关键可控因素。因此，应对所有嗓音障碍患者进行LPR筛查、嗓音声学检测随访，并对声带良性及癌前病变患者实施针对性LPR评估与管理，以优化嗓音治疗预后。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "黄萌"
    },
    {
      "name": "陈文勇"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ez04jmn0kcygh.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://www.chsr.cn/zh/article/doi/10.3969/j.issn.1672-4933.2026.05.009/",
  "id": "ez04jmn0kcygh",
  "issns": [
    "1672-4933"
  ],
  "landing_url": "http://www.chsr.cn/zh/article/doi/10.3969/j.issn.1672-4933.2026.05.009/",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Limited Liability Company of Chinese Scientific Journal of Hearing and Speech Rehabilitation",
  "ris": "https://research.draconitic.com/paper/ez04jmn0kcygh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:22Z",
      "native_id": "d6ccadc00e9f49f68a87a14d434979a4",
      "source": "doaj",
      "url": "http://www.chsr.cn/zh/article/doi/10.3969/j.issn.1672-4933.2026.05.009/"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:R",
      "subfield": "general"
    }
  ],
  "title": "咽喉反流与声带病变的相关性及其嗓音声学分析",
  "title_text": "咽喉反流与声带病变的相关性及其嗓音声学分析",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:22Z",
  "url": "https://research.draconitic.com/paper/ez04jmn0kcygh",
  "venue": "Zhongguo tingli yuyan kangfu kexue zazhi",
  "versions": []
}