{
  "abstract": "Tuberculosis (TB) remains a major global infectious disease, and novel host-derived biomarkers are needed to improve diagnosis. Circulating microRNAs (miRNAs) are promising biomarkers due to their stability and immune regulatory functions; however, clinically validated TB-associated miRNAs remain limited. This study aimed to identify circulating miRNAs associated with active pulmonary TB. This study included 90 participants: active pulmonary TB (n=30), cured TB (n=30), and healthy controls (n=30). Candidate miRNAs were screened by pooled plasma miRNA profiling and further examined using three publicly available miRNA datasets. Circulating miR-26b-5p was quantified by RT-qPCR. Associations with active TB status were assessed using logistic regression, and discriminatory performance was evaluated by ROC analysis. Putative miR-26b-5p target genes and enriched pathways were explored using bioinformatic analyses. Microarray screening identified 108 candidate miRNAs, and cross-dataset analysis identified miR-26b-5p as the only overlapping candidate with consistent downregulation. Circulating miR-26b-5p was lower in active TB and higher in the clinically cured group. It remained associated with active-TB status after adjustment for BMI and PLR. miR-26b-5p showed an AUC of 0.867, while the combined model achieved an AUC of 0.956. Bioinformatic analysis identified 74 putative genes, with EP300, GSK3B, and PTEN as network hubs and PI3K-Akt among the enriched pathways. Circulating miR-26b-5p was associated with active pulmonary TB and showed preliminary discriminatory value, supporting its further evaluation as a candidate host-response marker.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Infectious Diseases, Zhangjiajie People's Hospital, Zhangjiajie Hospital Affiliated to Hunan Normal University, Zhangjiajie, Hunan, People's Republic of China.",
    "The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, 410078, People's Republic of China.",
    "Jishou University, Xiangxi Tujia and Miao Autonomous Prefecture, Hunan, People's Republic of China.",
    "Department of Pulmonary Disease, The Fourth People's Hospital of Yiyang, Yiyang, Hunan, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhongrui Su"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianliang Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Wei Mo"
    },
    {
      "affs": [
        3
      ],
      "name": "Jin Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiyu Zeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Huiwen Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuangyin Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueming Xiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Kehua Xiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ez8vy0v4y6z9z.bib",
  "cited_by": 0,
  "doi": "10.2147/idr.s643442",
  "fulltext_url": "https://europepmc.org/articles/PMC13744184",
  "id": "ez8vy0v4y6z9z",
  "issns": [
    "1178-6973"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999617",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Tuberculosis Research and Epidemiology"
    ]
  ],
  "openalex": "W7225156906",
  "pdf_url": "https://europepmc.org/articles/PMC13744184?pdf=render",
  "pmcid": "PMC13744184",
  "pmid": "42999617",
  "published": "2026-11-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ez8vy0v4y6z9z.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42999617",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999617"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Tuberculosis Research and Epidemiology",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Circulating miR-26b-5p as a Potential Host-Derived Biomarker for Active Pulmonary Tuberculosis.",
  "title_text": "Circulating miR-26b-5p as a Potential Host-Derived Biomarker for Active Pulmonary Tuberculosis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/ez8vy0v4y6z9z",
  "venue": "Infection and drug resistance",
  "versions": []
}