{
  "abstract": "Objective Chronic rhinosinusitis (CRS) frequently coexists with bronchiectasis. Among the CRS phenotypes, CRS with nasal polyps (CRSwNP), which is predominantly characterized by type 2 (T2) inflammation, has been associated with bronchiectasis in Western populations. However, CRSwNP exhibits substantial inflammatory heterogeneity in Asia. From an inflammatory perspective, eosinophilic chronic rhinosinusitis (ECRS), a clinically defined CRS phenotype reflecting T2-dominant inflammation, may be more relevant to bronchiectasis. However, this association remains unclear. Methods We retrospectively analyzed patients aged ≥ 16 years who underwent paranasal sinus computed tomography (CT) followed by chest CT at a tertiary care center. The patients were classified into three groups: non-CRS, non-ECRS CRS, and ECRS groups. The association between CRS phenotypes and the presence of bronchiectasis was evaluated. Results A total of 74 patients were included (non-CRS, n = 39; non-ECRS CRS, n = 24; and ECRS, n = 11). The prevalence of bronchiectasis differed significantly among the groups: 31% in non-CRS, 42% in non-ECRS CRS, and 91% in ECRS (p = 0.001). In the multivariable analysis, increasing age [odds ratio (OR), 1.04; 95% confidence interval (CI), 1.00-1.07; p = 0.030] and ECRS (OR, 11.3; 95% CI, 1.15-111; p = 0.038) were independently associated with bronchiectasis. Conclusions ECRS is associated with bronchiectasis. These findings suggest that T2-dominant upper airway inflammation may contribute to the structural changes in the lower airways.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Yuta Kono"
    },
    {
      "name": "Akane Masuda"
    },
    {
      "name": "Ryo Maruyama"
    },
    {
      "name": "Haruka Motohashi"
    },
    {
      "name": "Mariko Kogami"
    },
    {
      "name": "Mayuko Ishiwari"
    },
    {
      "name": "Ryota Kikuchi"
    },
    {
      "name": "Kenichi Kobayashi"
    },
    {
      "name": "Yuki Togashi"
    },
    {
      "name": "Kiyoaki Tsukahara"
    },
    {
      "name": "Shinji Abe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eznpz1az3xmjx.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7390-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7390-26/_article",
  "id": "eznpz1az3xmjx",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7390-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2733|Sinusitis and nasal conditions"
    ]
  ],
  "openalex": "W7167922914",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7390-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eznpz1az3xmjx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7390-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7390-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Sinusitis and nasal conditions",
      "subfield": "general"
    }
  ],
  "title": "Association Between Eosinophilic Chronic Rhinosinusitis and Bronchiectasis in a Japanese Cohort",
  "title_text": "Association Between Eosinophilic Chronic Rhinosinusitis and Bronchiectasis in a Japanese Cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/eznpz1az3xmjx",
  "venue": "Internal Medicine",
  "versions": []
}