{
  "abstract": "In the present study, by building on the previous development of a DC-SIGN-targeting virus-like structure (VLS) vaccine platform and a comprehensive characterization of SARS-CoV-2 structural biology, particularly insights into the role of the nucleocapsid (N) protein in eliciting cytotoxic T lymphocyte (CTL) responses during infection, we designed a SARS-CoV-2 virion-mimetic structural vaccine that encapsulates an mRNA encoding the spike S1 antigen complexed with N protein complexes, with S1 proteins loaded on its surface. This characterized virion-mimetic structural vaccine not only induces the production of high-efficiency antibodies against both the spike and N proteins but also elicits robust S1-specific and N-specific CTL responses in animal models. Furthermore, the generated antibodies exhibit cross-reactive neutralizing activity against multiple SARS-CoV-2 variants and provide protective immunity against challenge with mutant viruses in immunized hosts. This SARS-CoV-2 virion-mimetic structure effectively recapitulates natural infection pathways, comprehensively activating the innate immune system and thereby creating an optimal microenvironment for eliciting potent and broad-spectrum adaptive immune responses.",
  "abstract_shown": true,
  "affiliations": [
    "Shandong WeigaoLitong Biological Products Co., Ltd.",
    "Weirui Biotechnology (Kunming) Co., Ltd., Ciba Biotechnology Innovation Center"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 30,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jingjing Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Fengyuan Zeng"
    },
    {
      "affs": [
        1
      ],
      "name": "Yanmei Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Yixuan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhenxiao Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Changyong Mu"
    },
    {
      "affs": [
        1
      ],
      "name": "Change Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yanrui Su"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaowu Peng"
    },
    {
      "affs": [
        1
      ],
      "name": "Lin Feng"
    },
    {
      "affs": [
        1
      ],
      "name": "Dongxiu Gao"
    },
    {
      "affs": [
        1
      ],
      "name": "Lichun Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "An Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Miaomiao Xing"
    },
    {
      "affs": [
        0
      ],
      "name": "Lihong Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Zixiong Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Huijuan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoxia Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Bing Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Lu Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Liping He"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhixiao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongbao Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Fang Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Lichun Zheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Fuyun He"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongkun Yi"
    },
    {
      "affs": [
        1
      ],
      "name": "Kaili Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Qihan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ezv6vt442jfxp.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-63144-4",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-63144-4",
  "id": "ezv6vt442jfxp",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-63144-4",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
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      "lcc",
      "R"
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    [
      "openalex",
      "2725|SARS-CoV-2 and COVID-19 Research"
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  "openalex": "W7170051686",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/ezv6vt442jfxp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:53Z",
      "native_id": "74c63f6c6e4e4ca58081ee3deee6c633",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-63144-4"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|SARS-CoV-2 and COVID-19 Research",
      "subfield": "infectious-disease"
    }
  ],
  "title": "A synthetic virus-like assembly unlocks dual-antigen presentation for broad-spectrum anti-SARS-CoV-2 immunity",
  "title_text": "A synthetic virus-like assembly unlocks dual-antigen presentation for broad-spectrum anti-SARS-CoV-2 immunity",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:53Z",
  "url": "https://research.draconitic.com/paper/ezv6vt442jfxp",
  "venue": "Scientific Reports",
  "versions": []
}