{
  "abstract": "Introduction\n\nTau positron emission tomography (PET) tracers differ in kinetics, binding properties, and quantification pipelines, complicating cross-study comparisons. The CenTauR approach provides a unified framework for harmonizing tau PET quantification across tracers.Methods\n\nWe defined a tracer-agnostic \"Standard Method\" using Statistical Parametric Mapping 12, standardized regions of interest, and harmonized acquisition parameters. Using data from five tau tracers-[¹⁸F]flortaucipir, [¹⁸F]MK-6240, [¹⁸F]PI-2620, [¹⁸F]RO948, and [¹⁸F]GTP1-we applied the Joint Propagation Model to derive linear equations converting regional standardized uptake value ratios into the tracer-independent CenTauR scale. Validation included independent cross-sectional, longitudinal, and test-retest datasets across multiple cohorts.Results\n\nThe CenTauR scale yielded highly consistent regional values across tracers, with strong cross-tracer agreement and robust performance in external validation cohorts. We also expressed clinically relevant cut-points and staging boundaries on the CenTauR scale.Discussion\n\nThe CenTauR approach enables harmonized, tracer-independent quantification of tau PET, supporting reproducibility across studies and improving interpretation in clinical research and multicenter trials.",
  "abstract_shown": true,
  "affiliations": [
    "ZRO Imaging, Santiago de Compostela, Spain.",
    "Nuclear Medicine Department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.",
    "Eli Lilly and Company, Indianapolis, Indiana, USA.",
    "Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.",
    "Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia.",
    "F. Hoffmann-La Roche Ltd, Basel, Switzerland.",
    "Clinical Imaging Group, Genentech, Inc., South San Francisco, California, USA.",
    "Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.",
    "Memory Clinic, Skåne University Hospital, Malmö, Sweden.",
    "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
    "Lawrence Berkeley National Laboratory, University of California Berkeley, Berkeley, California, USA.",
    "Johnson & Johnson, La Jolla, California, USA.",
    "Life Molecular Imaging GmbH, Berlin, Germany.",
    "Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.",
    "Lantheus Switzerland GmbH, Basel, Switzerland.",
    "Ace Alzheimer Center Barcelona, Barcelona, Spain.",
    "Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.",
    "Wisconsin Alzheimer's Disease Research Center, University of Wisconsin- Madison School of Medicine and Public Health, Madison, Wisconsin, USA.",
    "Department of Medicine Division of Geriatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.",
    "Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.",
    "Eisai, Inc., Nutley, New Jersey, USA.",
    "Biogen, Inc., Cambridge, Massachusetts, USA.",
    "Xing Imaging - AMitro Company, London, UK.",
    "Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.",
    "Merck & Co., West Point, Pennsylvania, USA.",
    "Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.",
    "Harvard Medical School, Department of Radiology, Boston, Massachusetts, USA.",
    "Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.",
    "Barcelonaβeta Brain Research Center, Barcelona, Spain.",
    "Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain.",
    "Critical Path for Alzheimer's Disease (CPAD) Consortium, Critical Path Institute, Tucson, Arizona, USA.",
    "Enigma Biomedical Group, Knoxville, Tennessee, USA.",
    "Neuroscience Campus Amsterdam, Alzheimer center, Amsterdam University Medical Center, Amsterdam, The Netherlands.",
    "Department of Nuclear Medicine & PET Center, Huashan University Hospital, Shanghai, China.",
    "Department of Nuclear Medicine, LMU Hospital, Ludwig Maximilian University of Munich, Munich, Germany.",
    "German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.",
    "Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.",
    "Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.",
    "Center of Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.",
    "Department of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA."
  ],
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  "bibtex": "https://research.draconitic.com/paper/f076nww06mwgq.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71886",
  "fulltext_url": "https://europepmc.org/articles/PMC13722786",
  "id": "f076nww06mwgq",
  "issns": [
    "1552-5260",
    "1552-5279"
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  "landing_url": "https://europepmc.org/article/MED/42963335",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
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      "2738|Dementia and Cognitive Impairment Research"
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  "pdf_url": "https://europepmc.org/articles/PMC13722786?pdf=render",
  "pmcid": "PMC13722786",
  "pmid": "42963335",
  "published": "2026-10-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/f076nww06mwgq.ris",
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      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
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  ],
  "title": "Tau positron emission tomography harmonization using the CenTauR approach: General conversion equations, relevant cut-points, and external validation.",
  "title_text": "Tau positron emission tomography harmonization using the CenTauR approach: General conversion equations, relevant cut-points, and external validation.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:32Z",
  "url": "https://research.draconitic.com/paper/f076nww06mwgq",
  "venue": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
  "versions": []
}