{
  "abstract": "Objectives\n\nInterstitial lung diseases (ILDs) are frequent and clinically important in SLE but diagnosis of ILD can be challenging. Thoracic ultrasound (TUS) shows promise in detecting ILD, hence, we aimed to evaluate the utility of TUS to identify ILD in SLE.Methods\n\nPatients fulfilling the EULAR/ACR 2019 SLE classification criteria were invited. Participants were assessed for ILD by means of chest high-resolution computed tomography scans and pulmonary function tests and diagnosed at a multidisciplinary discussion, according to reference standards, independent of TUS. TUS evaluated the presence of B-lines and pleural abnormalities, blinded to status of ILD. The ability of B-lines to identify ILD using a prespecified threshold of ≥10 B-lines was analysed using diagnostic test accuracy measures. Further, we explored the diagnostic performance of B-lines and pleural abnormalities to identify ILD across various scenarios.Results\n\nAmong 185 patients with SLE, ILD were present in 22 (12%). With the predefined threshold of ≥10 B-lines, we found a modest diagnostic test accuracy as 14 of 22 ILD cases were classified as abnormal TUS, with diagnostic odds ratio of 10.7 (3.2-32.3), sensitivity of 64% (41-83%) and negative predictive value 97% (90-98%). In exploratory analyses, excluding participants with certain characteristics possibly affecting the TUS from the analyses improved the performance of TUS and pleural abnormalities were associated with ILD.Conclusion\n\nIn SLE, TUS focusing on the presence of B-lines demonstrated modest but statistically significant diagnostic test accuracy for detecting ILD. Pleural abnormalities were significantly associated to ILD.",
  "abstract_shown": true,
  "affiliations": [
    "Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.",
    "Department of Rheumatology, Midt og Vestsjællands Sygehus, Slagelse, Denmark.",
    "Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.",
    "South Danish Center for Interstitial Lung Diseases (SCILS) and Pulmo-Rheuma Frontline Center (PURE), Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.",
    "Research Unit of Department of Radiology, University of Southern Denmark, Odense University Hospital, Odense, Denmark.",
    "Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.",
    "Systemic Lupus Erythematosus Patient Research Partner, Department of Rheumatology, Odense University Hospital, Odense, Denmark.",
    "Section for Biostatistics and Evidence-Based Research, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Henrik Zachar Langkilde",
      "orcid": "0000-0002-3700-0755"
    },
    {
      "affs": [
        0
      ],
      "name": "Bjørk K Sofíudóttir",
      "orcid": "0000-0002-5918-3206"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Jesper Rømhild Davidsen",
      "orcid": "0000-0003-4128-4014"
    },
    {
      "affs": [
        4
      ],
      "name": "Stefan Markus Walbom Harders",
      "orcid": "0000-0001-9002-6375"
    },
    {
      "affs": [
        2
      ],
      "name": "Stefan Møller Luef",
      "orcid": "0000-0003-2384-4137"
    },
    {
      "affs": [
        0
      ],
      "name": "Susan Due Kay"
    },
    {
      "affs": [
        5
      ],
      "name": "Elisabet Svenungsson",
      "orcid": "0000-0003-3396-3244"
    },
    {
      "affs": [
        6
      ],
      "name": "Sille Fløjborg"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Robin Christensen",
      "orcid": "0000-0002-6600-0631"
    },
    {
      "affs": [
        0
      ],
      "name": "Anne Voss",
      "orcid": "0000-0001-6582-2636"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f07cdh6cnbnhy.bib",
  "cited_by": 0,
  "doi": "10.1093/rap/rkag126",
  "fulltext_url": "https://europepmc.org/articles/PMC13713183",
  "id": "f07cdh6cnbnhy",
  "issns": [
    "2514-1775"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948844",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00010"
    ],
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2706|Ultrasound in Clinical Applications"
    ]
  ],
  "openalex": "W7221807484",
  "pdf_url": "https://europepmc.org/articles/PMC13713183?pdf=render",
  "pmcid": "PMC13713183",
  "pmid": "42948844",
  "published": "2026-10-14",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/f07cdh6cnbnhy.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42948844",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948844"
    },
    {
      "first_seen": "2026-10-31T12:23:34Z",
      "native_id": "PMC13713183",
      "source": "pmc",
      "url": "https://doi.org/10.1093/rap/rkag126"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2706|Ultrasound in Clinical Applications",
      "subfield": "general"
    }
  ],
  "title": "Thoracic ultrasound finding interstitial lung disease in SLE: a diagnostic test accuracy study.",
  "title_text": "Thoracic ultrasound finding interstitial lung disease in SLE: a diagnostic test accuracy study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:23:34Z",
  "url": "https://research.draconitic.com/paper/f07cdh6cnbnhy",
  "venue": "Rheumatology advances in practice",
  "versions": []
}