{
  "abstract": "Ovarian cancer is one of the deadliest gynecological cancers worldwide. One promising therapeutic approach is the use of combined biomarkers. The Risk of Ovarian Malignancy Algorithm (ROMA) which combines CA125 with Human Epididymal Protein 4 (HE4) is an example of combining biomarkers to gain an optimal predictive outcome. Tumor Protein p53 (TP53) is a transcription factor with tumor suppressor properties. Mutations in TP53 constitute the most frequent genetic alterations observed in ovarian cancer. In contrast to conventional markers such as CA125, circulating tumor DNA (ctDNA) provides information about tumor mutations and insights into treatment response. Analysis of ctDNA enables the identification of tumor-associated mutations. Non-coding RNAs (ncRNAs) also influence cellular processes and act as effectors in oncogenic pathways by binding to RNA or proteins. One effector is Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1), whose increased expression is associated with an aggressive tumor phenotype. MicroRNAs (miRNAs) are crucial in regulating the expression of genes associated with ovarian cancer development and progression. Exosomes carrying various molecules, including miRNAs and lncRNAs, contribute to ovarian cancer progression. Adipocytokines play an important role in the regulation of metabolic and inflammatory processes. Despite their diagnostic potential, the identified biomarkers require further validation.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland",
    "University College London Medical School, London WC1E 6DE, UK",
    "Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland",
    "Prestage Department of Poultry Science, North Carolina State University, Raleigh, NC 27695, USA",
    "Physiology Graduate Faculty, North Carolina State University, Raleigh, NC 27695, USA",
    "Institute of Medical Sciences, Adam Mickiewicz University, 64-920 Piła, Poland",
    "Department of Human Biology, Faculty of Physiotherapy, Wroclaw, University of Health and Sport Sciences, 51-612 Wroclaw, Poland",
    "Center of Assisted Reproduction, Department of Obstetrics and Gynecology, University Hospital and Masaryk University, 625 00 Brno, Czech Republic",
    "Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland",
    "Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, 8091 Zurich, Switzerland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Julia Niebora"
    },
    {
      "affs": [
        1
      ],
      "name": "Julia Spaczyńska"
    },
    {
      "affs": [
        2
      ],
      "name": "Aleksandra Partyńska",
      "orcid": "0000-0002-7532-0397"
    },
    {
      "affs": [
        0
      ],
      "name": "Natalia Penciak",
      "orcid": "0009-0000-8011-6051"
    },
    {
      "affs": [
        0
      ],
      "name": "Dominika Domagała",
      "orcid": "0009-0008-5220-7851"
    },
    {
      "affs": [
        0
      ],
      "name": "Krzysztof Data",
      "orcid": "0000-0002-9018-5357"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Paul Mozdziak",
      "orcid": "0000-0002-1575-3123"
    },
    {
      "affs": [
        0
      ],
      "name": "Artur Bryja"
    },
    {
      "affs": [
        0
      ],
      "name": "Piotr P. Chmielewski",
      "orcid": "0000-0002-6995-123X"
    },
    {
      "affs": [
        0
      ],
      "name": "Paweł Dąbrowski",
      "orcid": "0000-0001-6016-9201"
    },
    {
      "affs": [
        2,
        5
      ],
      "name": "Teresa Wysocka"
    },
    {
      "affs": [
        2,
        5
      ],
      "name": "Maciej Zabel"
    },
    {
      "affs": [
        2,
        6
      ],
      "name": "Marzenna Podhorska-Okołów"
    },
    {
      "affs": [
        2,
        6
      ],
      "name": "Piotr Dzięgiel"
    },
    {
      "affs": [
        0,
        3,
        4,
        7,
        8
      ],
      "name": "Bartosz Kempisty"
    },
    {
      "affs": [
        9
      ],
      "name": "Ievgeniia Kocherova"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f0cd9gesd0khc.bib",
  "cited_by": 0,
  "doi": "10.3390/cells15211940",
  "fulltext_url": null,
  "id": "f0cd9gesd0khc",
  "issns": [
    "2073-4409"
  ],
  "landing_url": "https://www.mdpi.com/2073-4409/15/21/1940",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2743|Ovarian cancer diagnosis and treatment"
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  "openalex": "W7223649035",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/f0cd9gesd0khc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:02Z",
      "native_id": "10.3390/cells15211940",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4409/15/21/1940"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Ovarian cancer diagnosis and treatment",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Advances in Biomarker Discovery for Early Ovarian Cancer Diagnosis",
  "title_text": "Advances in Biomarker Discovery for Early Ovarian Cancer Diagnosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:02Z",
  "url": "https://research.draconitic.com/paper/f0cd9gesd0khc",
  "venue": "Cells",
  "versions": []
}