{
  "abstract": "A direct approach to SuFEx-active 2H-indazoles from azobenzenes and ethenesulfonyl fluoride was developed through Rh(iii)-catalyzed tandem C-H activation and annulation. The transformation provided a range of SO₂F-containing 2H-indazoles with good functional group tolerance while preserving the synthetically valuable sulfonyl fluoride functionality. The practicality of the method was demonstrated by gram-scale synthesis and subsequent SuFEx conjugation with representative biologically relevant molecules. This strategy provides efficient access to functionalized 2H-indazoles bearing a versatile SuFEx handle for further molecular diversification in medicinal chemistry and chemical biology.",
  "abstract_shown": true,
  "affiliations": [
    "College of Pharmacy, Korea University Sejong 30019 Republic of Korea hans3@Korea.ac.kr.",
    "Institute of Pharmaceutical Science and Translational Research, Korea University Sejong 30019 Republic of Korea.",
    "Department of Innovative Pharmaceutical Sciences, Kyungpook National University Daegu 41566 Republic of Korea sangil.han@knu.ac.kr.",
    "College of Pharmacy, Research Institute of Pharmaceutical Sciences, Sookmyung Women's University Seoul 04310 Republic of Korea.",
    "Department of Chemistry, Sungkyunkwan University Suwon 16419 Republic of Korea hybae@skku.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lingayya Rajaka",
      "orcid": "0000-0001-7114-2936"
    },
    {
      "affs": [
        0
      ],
      "name": "Hyosik Woo",
      "orcid": "0009-0004-6684-6858"
    },
    {
      "affs": [
        0
      ],
      "name": "Myunghwa Jung"
    },
    {
      "affs": [
        2
      ],
      "name": "Chanhee Jang"
    },
    {
      "affs": [
        0
      ],
      "name": "Seungwan Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Jihyo Lee"
    },
    {
      "affs": [
        3
      ],
      "name": "Saegun Kim",
      "orcid": "0009-0002-2838-9014"
    },
    {
      "affs": [
        2
      ],
      "name": "Sangil Han",
      "orcid": "0000-0003-1562-3254"
    },
    {
      "affs": [
        4
      ],
      "name": "Han Yong Bae",
      "orcid": "0000-0002-7559-7919"
    },
    {
      "affs": [
        0
      ],
      "name": "Sang Hoon Han",
      "orcid": "0000-0002-2016-354X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f0cp9hjek38yj.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra09632h",
  "fulltext_url": "https://europepmc.org/articles/PMC13678690",
  "id": "f0cp9hjek38yj",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898774",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Sulfur-Based Synthesis Techniques"
    ]
  ],
  "openalex": "W7222948825",
  "pdf_url": "https://europepmc.org/articles/PMC13678690?pdf=render",
  "pmcid": "PMC13678690",
  "pmid": "42898774",
  "published": "2026-10-19",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/f0cp9hjek38yj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42898774",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898774"
    },
    {
      "first_seen": "2026-11-07T12:23:34Z",
      "native_id": "PMC13678690",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra09632h"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Sulfur-Based Synthesis Techniques",
      "subfield": "organic"
    }
  ],
  "title": "Synthesis and diversification of SuFEx-active 2H-indazoles from azobenzenes and ethenesulfonyl fluoride.",
  "title_text": "Synthesis and diversification of SuFEx-active 2H-indazoles from azobenzenes and ethenesulfonyl fluoride.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:02Z",
  "url": "https://research.draconitic.com/paper/f0cp9hjek38yj",
  "venue": "RSC advances",
  "versions": []
}