{
  "abstract": "BACKGROUND: Late-onset epilepsy of unknown aetiology (LOEU) represents a prevalent and often disabling neurological disorder. Existing studies indicate that cerebral small vessel disease (cSVD) may play a significant role in the pathogenesis of epilepsy within this population; however, prospective investigations are currently lacking. We aimed to systematically describe the burden and qualitative aspects of cSVD in a LOEU population. METHODS: Patients with LOEU were prospectively included across three university hospitals (Nancy, Lille and Reims, France). Patients were systematically assessed for clinical, cardiovascular, neurophysiological (EEG, polygraphy/polysomnography), neuropsychological, and radiological features (brain MRI and FDG-PET). cSVD was assessed using MRI only. A composite score evaluating WMH, microbleeds, EPVS, and lacunar infarcts was used. Moderate-to-severe cSVD was defined as a score of 2 4. RESULTS: A total of 55 patients were enrolled, predominantly male (63.6%), with a median age of 71yo (IQR 12.7) and multiple cardiovascular risk factors. Moderate-to severe cSVD was infrequent in this cohort (23.6%). No significant association was observed between cSVD score and epilepsy characteristics. Objective cognitive impairment was prevalent but was not associated with a higher burden of cSVD. Multivariate logistic regression identified advanced age as the sole significant factor associated with moderate-to-severe cSVD. CONCLUSION: In this thoroughly characterized cohort, moderate-to-severe cSVD was infrequent, with age identified as the sole risk factor. These findings support the hypothesis that cSVD may serve as a biomarker of brain aging. Further research is required to substantiate these results.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Emmanuelle Hologne"
    },
    {
      "name": "Floriane Machet"
    },
    {
      "name": "Salomé Puisieux"
    },
    {
      "name": "Dimitri Papathanassiou"
    },
    {
      "name": "Claire Launois"
    },
    {
      "name": "Ruben Wanono"
    },
    {
      "name": "Victoire Martin"
    },
    {
      "name": "Antoine Verger"
    },
    {
      "name": "Yaohua Chen"
    },
    {
      "name": "Louise Tyvaert"
    },
    {
      "name": "Solène Moulin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f0eztpkh3xnrb.bib",
  "cited_by": 0,
  "doi": "10.1016/j.seizure.2026.09.007",
  "fulltext_url": null,
  "id": "f0eztpkh3xnrb",
  "issns": [
    "1059-1311"
  ],
  "landing_url": "https://hal.science/hal-05753412v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "openalex",
      "2738|Epilepsy research and treatment"
    ]
  ],
  "openalex": "W7212370907",
  "pdf_url": "https://www.seizure-journal.com/article/S1059-1311(26)00272-4/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-17",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/f0eztpkh3xnrb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "hal-05753412",
      "source": "hal",
      "url": "https://hal.science/hal-05753412v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Epilepsy research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "Cerebral small vessel disease burden in late-onset epilepsy of unknown aetiology: insights from a prospective multicenter cohort",
  "title_text": "Cerebral small vessel disease burden in late-onset epilepsy of unknown aetiology: insights from a prospective multicenter cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/f0eztpkh3xnrb",
  "venue": "Seizure - European Journal of Epilepsy",
  "versions": []
}