{
  "abstract": "IntroductionFecal calprotectin (FC) results may be unavailable during assessment of inflammatory or ulcerative intestinal lesions. We assessed FC documentation and developed a diagnostic prediction model using endoscopic features and blood-derived inflammatory indices for ulcerative colitis (UC).MethodsWe retrospectively included 655 patients from four centers. Four prespecified logistic models were compared in complete cases (N = 455; 103 UC cases). Performance included discrimination, Brier score, calibration, and decision curves. Internal validation used 1,000 bootstrap resamples; transportability was assessed by leave-one-center-out cross-validation. LASSO-based analyses were exploratory; multiple imputation also assessed the robustness of the four primary models.ResultsFC was documented in 6 patients (0.9%). A model combining mucosal granularity, mucosal edema, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index had an apparent area under the receiver operating characteristic curve (AUC) of 0.739 (95% CI 0.684–0.795) and an optimism-corrected AUC of 0.733. It exceeded the blood-derived index model (AUC=0.594, P < 0.001) and simplified endoscopic model (AUC = 0.711, P = 0.024), but did not differ significantly from the three-item endoscopic model comprising vascular pattern abnormality, bleeding, and erosions/ulcers (AUC = 0.758, P = 0.521). At a cutoff of 0.155, Negative predictive value was 0.901. LASSO selected vascular pattern abnormality, bleeding, and mucosal granularity (optimism-corrected AUC = 0.746).DiscussionThe combined model showed moderate discrimination, with modest incremental value from blood-derived indices.",
  "abstract_shown": true,
  "affiliations": [
    "Guangxi University of Chinese Medicine, Nanning, Guangxi, China",
    "Department of Gastroenterology, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China",
    "Department of Gastroenterology, Guilin Hospital of Integrated Traditional Chinese and Western Medicine, Guilin, Guangxi, China",
    "Department of Gastroenterology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, China",
    "Department of Gastroenterology, Guidong People’s Hospital of Guangxi Zhuang Autonomous Region, Wuzhou, Guangxi, China",
    "Department of Gastroenterology, Affiliated Wuxi Hospital of Nanjing University of Chinese Medicine, Wuxi, Jiangsu, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yunlong Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Dongyu Cheng"
    },
    {
      "affs": [
        2
      ],
      "name": "Hairong Huang"
    },
    {
      "affs": [
        3
      ],
      "name": "Dongping Lai"
    },
    {
      "affs": [
        4
      ],
      "name": "Ri'an Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Dadong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hao Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Linyan Shen"
    },
    {
      "affs": [
        5
      ],
      "name": "Tao Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f0sbx4w3vv01k.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1991253",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fmed.2026.1991253/full",
  "id": "f0sbx4w3vv01k",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://doi.org/10.3389/fmed.2026.1991253",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7223651609",
  "pdf_url": "https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1991253/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/f0sbx4w3vv01k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:23Z",
      "native_id": "e537f4946788456093b8f287db903301",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fmed.2026.1991253"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Diagnostic prediction of ulcerative colitis using simplified endoscopic features and blood count-derived indices: a multicenter study",
  "title_text": "Diagnostic prediction of ulcerative colitis using simplified endoscopic features and blood count-derived indices: a multicenter study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:23Z",
  "url": "https://research.draconitic.com/paper/f0sbx4w3vv01k",
  "venue": "Frontiers in Medicine",
  "versions": []
}