{
  "abstract": "Rheumatoid arthritis (RA) is characterized by persistent synovial inflammation and progressive bone destruction. Transcriptomic profiling identified hyperactivated B cells as key contributors to osteoimmune dysregulation, supporting localized B cell intervention as a therapeutic strategy. Here, an injectable thermosensitive hydroxypropyl chitin hydrogel incorporating Cu/Zn-doped bioactive glass particles, termed BG@HPCH, was developed for localized metalloimmunotherapy. BG incorporation improved the shear-thinning behavior, thermosensitive gelation, storage modulus, and stability of the hydrogel. In vitro, ionic release from BG@HPCH selectively reduced pathogenic B cell survival while preserving mesenchymal stem cell (MSC) viability. The optimized M-BG@HPCH increased the B cell dead-cell area from 1.93 ± 0.48% to 91.12 ± 0.90% at 24 h, while maintaining MSC viability at 98.59 ± 0.26% after 3 days. In TNF-transgenic mice, a single intra-articular injection of BG@HPCH reduced arthritis index scores from 2.88 ± 0.18 to 1.81 ± 0.13 at day 28, limited bone erosion, and showed no detectable systemic toxicity. Micro-CT analysis showed improved bone preservation, with BV/TV increasing from 30.00 ± 6.74% to 55.66 ± 1.07%. OCN staining further confirmed enhanced osteogenic activity, with the OCN + area increasing by 2.16 times. Flow cytometry confirmed reduced B220 + CD45.2 + B cell accumulation in treated joints. Single-cell RNA sequencing of 23,921 joint cells showed that BG@HPCH reduced inflammatory B cell, macrophage, and fibroblast subsets while expanding osteoblast-associated regenerative populations, accompanied by suppression of CD23 − and CD74-associated B cell signaling axes. These findings establish BG@HPCH as a localized immunoregenerative biomaterial for coordinating pathogenic B cell depletion and bone repair in RA.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Basic Science of Stomatology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210029, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210029, China; State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Nanjing, 210029, China",
    "Department of Basic Science of Stomatology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210029, China; State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Nanjing, 210029, China",
    "Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China",
    "Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing, Medical University, Nanjing, China",
    "Department of Science Service, Ministry of Higher Education, Science, Research and Innovation, Bangkok, 10400, Thailand"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
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        0
      ],
      "name": "Ziwei Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yue Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Fanrui Zeng"
    },
    {
      "affs": [
        1
      ],
      "name": "Qing Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Hanjia Cai"
    },
    {
      "affs": [
        2
      ],
      "name": "Ran Qin"
    },
    {
      "affs": [
        1
      ],
      "name": "JunYi Xu"
    },
    {
      "affs": [
        3
      ],
      "name": "Bingjie Gu"
    },
    {
      "affs": [
        0
      ],
      "name": "Laikui Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Usanee Pantulap"
    },
    {
      "name": "Kai Zheng"
    },
    {
      "name": "Wen Sun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f13anhpwevsa9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bioactmat.2026.08.057",
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  "landing_url": "https://doi.org/10.1016/j.bioactmat.2026.08.057",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
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  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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      "openalex",
      "2745|Rheumatoid Arthritis Research and Therapies"
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  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718892/pdf/?tool=EBI",
  "pmcid": "PMC13718892",
  "pmid": "42959986",
  "published": "2026-10-23",
  "publisher": "KeAi Communications Co., Ltd.",
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  "subjects": [
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      "field": "medicine",
      "origin": "openalex:2745|Rheumatoid Arthritis Research and Therapies",
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  ],
  "title": "Injectable bioactive glass hydrogels orchestrate metalloimmunotherapy by depleting pathogenic B cells and rescuing bone in rheumatoid arthritis",
  "title_text": "Injectable bioactive glass hydrogels orchestrate metalloimmunotherapy by depleting pathogenic B cells and rescuing bone in rheumatoid arthritis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:50Z",
  "url": "https://research.draconitic.com/paper/f13anhpwevsa9",
  "venue": "Bioactive Materials",
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}