{
  "abstract": "Background: : Primary biliary cholangitis (PBC) is a rare autoimmune liver disease with limited epidemiological data from Latin America.\n\nObjectives: : To analyzed nationwide trends in PBC-related hospitalizations and in-hospital mortality within Brazil’s Unified Health System (SUS) from 2015 to 2024.\n\nMethods: : National hospital admission data for ICD-10 code K74.3 were analyzed. Hospitalization rates per 100,000 inhabitants, in-hospital mortality, costs, and mean length of stay were estimated. Temporal changes were assessed using interrupted time-series segmented regression, and descriptive analyses were stratified into pre-pandemic, pandemic (COVID-19), and post-pandemic periods.\n\nResults: : Between 2015 and 2024, 2,913 hospitalizations were recorded. The annual hospitalization rate ranged from 0.11 per 100,000 in 2022 to 0.19 per 100,000 in 2020, with a mean of 0.15 per 100,000 over the study period. Mean admission-level in-hospital mortality was 15.4%, ranging from 11.7%-18.5%. Mean length of stay was 7.9 days, with little variation over time. A transient increase in hospitalizations was observed in 2020 (β2 = +0.046, P=0.03), followed by a negative slope change in the post-2020 period (β2 = −0.009, P=0.04), suggesting temporary disruption related to the COVID-19 pandemic. The Southeast had the highest hospitalization burden. Inflation-adjusted expenditures totaled R$ 11.38 million (USD 2,112,227.43), with a mean cost of R$ 3,908 (USD 725.10) per admission.\n\nConclusion: : PBC-coded hospitalizations in Brazil are infrequent but associated with substantial in-hospital mortality. Strengthening outpatient management and regional equity in hepatology care remains a public health priority.",
  "abstract_shown": true,
  "affiliations": [
    "Universidade Federal de Minas Gerais, Hospital das Clínicas, Instituto Alfa de Gastroenterologia, Belo Horizonte, MG, Brasil.",
    "Hospital da Polícia Militar de Minas Gerais, Departamento de Gastroenterologia e Hepatologia, Belo Horizonte, MG, Brasil.",
    "Hospital Português, Salvador, BA, Brasil.",
    "Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Hospital Universitário Clementino Fraga Filho, Departamento de Clínica Médica, Rio de Janeiro, RJ, Brasil.",
    "Universidade de São Paulo, Departamento de Gastroenterologia, São Paulo, SP, Brasil.",
    "Universidade Federal de São Paulo, Disciplina de Gastroenterologia, São Paulo, SP, Brasil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Guilherme Grossi Lopes CANÇADO",
      "orcid": "0000-0002-7824-2152"
    },
    {
      "affs": [
        0
      ],
      "name": "Cláudia Alves COUTO",
      "orcid": "0000-0002-9776-4757"
    },
    {
      "affs": [
        0
      ],
      "name": "Luciana Costa FARIA",
      "orcid": "0000-0002-0226-3491"
    },
    {
      "affs": [
        0
      ],
      "name": "Bernardo de Faria MORAES",
      "orcid": "0009-0004-3537-8289"
    },
    {
      "affs": [
        2
      ],
      "name": "Paulo Lisboa BITTENCOURT",
      "orcid": "0000-0003-0883-4870"
    },
    {
      "affs": [
        3
      ],
      "name": "Cristiane Alves Villela-Nogueira",
      "orcid": "0000-0003-1355-2368"
    },
    {
      "affs": [
        3
      ],
      "name": "Vivian ROTMAN",
      "orcid": "0000-0003-0522-396X"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Debora Raquel Benedita TERRABUIO",
      "orcid": "0000-0003-4072-1761"
    },
    {
      "affs": [
        4
      ],
      "name": "Eduardo Luiz Rachid CANÇADO",
      "orcid": "0000-0002-9309-1524"
    },
    {
      "affs": [
        5
      ],
      "name": "Maria Lúcia FERRAZ",
      "orcid": "0000-0001-8992-8494"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f14znpm4z9q3y.bib",
  "cited_by": 0,
  "doi": "10.1590/s0004-2803.24612026-070",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722406/?tool=EBI",
  "id": "f14znpm4z9q3y",
  "issns": [
    "0004-2803",
    "1678-4219"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13722406",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "ORIGINAL ARTICLE/Hepatology"
    ],
    [
      "openalex",
      "2721|Liver Diseases and Immunity"
    ]
  ],
  "openalex": "W7224802148",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722406/pdf/?tool=EBI",
  "pmcid": "PMC13722406",
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e outras Especialidades",
  "ris": "https://research.draconitic.com/paper/f14znpm4z9q3y.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13722406",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722406"
    },
    {
      "first_seen": "2026-11-03T12:22:54Z",
      "native_id": "PMC13722406",
      "source": "pmc",
      "url": "https://doi.org/10.1590/s0004-2803.24612026-070"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver Diseases and Immunity",
      "subfield": "general"
    }
  ],
  "title": "TRENDS IN HOSPITALIZATIONS, COSTS, AND IN-HOSPITAL MORTALITY IN PRIMARY BILIARY CHOLANGITIS: A DECADE OF REAL-WORLD EVIDENCE FROM BRAZIL’S UNIFIED HEALTH SYSTEM Tendências nas hospitalizações, custos e mortalidade intra-hospitalar por colangite biliar primária: uma década de evidências de mundo real do Sistema Único de Saúde do Brasil",
  "title_text": "TRENDS IN HOSPITALIZATIONS, COSTS, AND IN-HOSPITAL MORTALITY IN PRIMARY BILIARY CHOLANGITIS: A DECADE OF REAL-WORLD EVIDENCE FROM BRAZIL’S UNIFIED HEALTH SYSTEM Tendências nas hospitalizações, custos e mortalidade intra-hospitalar por colangite biliar primária: uma década de evidências de mundo real do Sistema Único de Saúde do Brasil",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:54Z",
  "url": "https://research.draconitic.com/paper/f14znpm4z9q3y",
  "venue": "Arquivos de gastroenterologia",
  "versions": []
}