{
  "abstract": "A practice-specific stimulation experiment requires candidate montages that differ in regional electric-field exposure without sacrificing interpretable target dose. We evaluated this requirement for transcranial direct current stimulation (tDCS) montages intended to test focused-attention and open-monitoring mindfulness practices. Four focused-attention candidates and six open-monitoring candidates formed 24 pairs, evaluated with SimNIBS 4.6 in 20 existing anatomical head models at a linearly scaled current of 2 mA. Outcomes were regional 99th-percentile field magnitude, a normalized double-dissociation index (DDI), suprathreshold overlap, and individual dose coverage. Eighteen pairs passed four recorded progression criteria, but only five also met a post hoc requirement that both intended regional contrasts be positive in at least 80% of heads. A positive DDI alone concealed a reversed salience-region contrast in one conventional comparison. The nominated F3-centered 4-by-1 ring paired with F8-Fp2 sponges (FA-05 x OM-02) produced both directional preferences in 20/20 heads, with median DDI 1.561 and median suprathreshold Dice 0.000. The conventional F3-Fp2 and FT8-FCz sponge pair (FA-02 x OM-07) produced both preferences in 19/20 heads, with DDI 0.627 and Dice 0.186. Both anatomical targets reached the operational 0.20 V/m floor in 11/20 versus 20/20 heads, respectively. ROAST 4.0, with ring placement held fixed, supported both nominations but exposed dose disagreement. Across conductivity sensitivity draws, directional separability persisted more consistently than absolute dose. These results establish a regional separability-dose trade-off within the tested candidate set and show why a summed contrast cannot substitute for a directional conjunction. They support selection of a discriminating experiment, not whole-network selectivity, physiological efficacy, or a validated treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Sunkara Wellness Technologies"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "D. L. Bruschi"
    },
    {
      "name": "A. Schiavi"
    },
    {
      "name": "I. Joseph"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f16k38wwxrxqt.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.07.757440",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757440v1.full",
  "id": "f16k38wwxrxqt",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757440v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2808|Transcranial Magnetic Stimulation Studies"
    ]
  ],
  "openalex": "W7222342925",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757440v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/f16k38wwxrxqt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:54Z",
      "native_id": "10.64898/2026.10.07.757440",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757440v3"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Computational Evaluation of tDCS Montage Separability and Dose Coverage for Practice-Specific Mindfulness Experiments",
  "title_text": "Computational Evaluation of tDCS Montage Separability and Dose Coverage for Practice-Specific Mindfulness Experiments",
  "type": "preprint",
  "updated_at": "2026-11-05T00:20:52Z",
  "url": "https://research.draconitic.com/paper/f16k38wwxrxqt",
  "venue": "bioRxiv",
  "versions": []
}