{
  "abstract": "Background: Isolated proctitis (IP) affects a third of patients with ulcerative colitis. The long-term effectiveness of medical therapies in IP is still unclear.\n\nObjective: To assess the effectiveness of medical therapies in IP.\n\nDesign: A retrospective observational cohort study using data from the NIHR IBD BioResource registered between April 4, 2016, and January 3, 2025.\n\nResults: A total of 8346 patients with IP were included. The probability of treatment escalation from 5-aminosalicylates (5-ASAs) was 11.1%, 21.5%, and 27.3% at 1, 3, and 5 years respectively. Age onset >40 years was associated with a lower risk (hazard ratio [HR] = 0.552, 95% confidence interval [CI]: 0.491-0.621) and presence of extra-intestinal manifestations (EIMs) associated with a higher risk (HR = 1.701, 95% CI: 1.432-2.020) of treatment escalation. The probability of treatment escalation from thiopurines was 14%, 24.4%, and 30.8% at 1, 3, and 5 years respectively. Montreal classification A3 (HR = 0.707, 95% CI: 0.597-0.836) and longer disease duration (HR = 0.983, 95% CI: 0.972-0.995) were associated with a lower risk, while co-diagnosis of EIM indicated a higher risk (HR = 1.513, 95% CI: 1.209-1.894) of treatment escalation. Compared to infliximab, adalimumab (odds ratio [OR] 0.537, 95% CI: 0.416-0.692) and golimumab (OR 0.361, 95% CI: 0.206-0.618) were associated with reduced odds, while anti-integrin exposure was associated with an increased odds of treatment response (OR 2.033, 95% CI: 1.529-2.720).\n\nConclusion: Among the available advanced therapies evaluated, anti-integrin therapy was associated with the highest treatment persistence and response rates in this real-world cohort of IP. Further clinical trials are warranted in IP.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Kaung Yan"
    },
    {
      "name": "Sudheer Kumar Vuyyuru"
    },
    {
      "name": "Shellie Radford",
      "orcid": "0000-0002-2226-0810"
    },
    {
      "name": "Adam Taylor",
      "orcid": "0009-0003-4651-041X"
    },
    {
      "name": "Burak Sahin",
      "orcid": "0009-0008-2767-8467"
    },
    {
      "name": "Bamidele Famokunwa",
      "orcid": "0000-0002-5608-6072"
    },
    {
      "name": "Gordon W Moran",
      "orcid": "0000-0002-8906-6908"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f1jsrkrvhvcdg.bib",
  "cited_by": 0,
  "doi": "10.1093/crocol/otag118",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728847/?tool=EBI",
  "id": "f1jsrkrvhvcdg",
  "issns": [
    "2631-827X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13728847",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00260"
    ],
    [
      "heading",
      "AcademicSubjects/MED00760"
    ],
    [
      "heading",
      "AcademicSubjects/MED00972"
    ],
    [
      "heading",
      "Observations and Research"
    ],
    [
      "openalex",
      "2715|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7222853591",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728847/pdf/?tool=EBI",
  "pmcid": "PMC13728847",
  "pmid": "42979188",
  "published": "2026-10-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/f1jsrkrvhvcdg.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "PMC:PMC13728847",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13728847"
    },
    {
      "first_seen": "2026-11-07T12:21:44Z",
      "native_id": "PMC13728847",
      "source": "pmc",
      "url": "https://doi.org/10.1093/crocol/otag118"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Inflammatory Bowel Disease",
      "subfield": "general"
    }
  ],
  "title": "Bridging the evidence gap in isolated proctitis: real-world evidence on medical therapies for isolated proctitis—a nation-wide analysis using data of 8346 patients from UK IBD BioResource",
  "title_text": "Bridging the evidence gap in isolated proctitis: real-world evidence on medical therapies for isolated proctitis—a nation-wide analysis using data of 8346 patients from UK IBD BioResource",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:44Z",
  "url": "https://research.draconitic.com/paper/f1jsrkrvhvcdg",
  "venue": "Crohn's & colitis 360",
  "versions": []
}