{ "abstract": "Background/Objectives: Evidence on the effectiveness of spinal cord stimulation using fast-acting subperception therapy (FAST-SCS) in patients with persistent spinal pain syndrome (PSPS) remains limited. We evaluated clinical outcomes of FAST-SCS in patients with PSPS types 1 (i.e., non-surgical back pain) and 2 (i.e., failed back surgery syndrome). Methods: Our global, multicenter, retrospective, observational chart review included all consecutive adults with chronic low back and/or leg pain due to PSPS who received SCS with a multimodal device and reported using FAST-SCS at their latest follow-up. Available data from the patients’ medical files, documented by site personnel per their standard of care, were collected and analyzed. Pain intensity was assessed using the numerical rating scale (NRS); percent pain relief (PPR) was recorded where available. Main outcomes included changes in overall pain (NRS) compared to baseline, proportion of patients with ≥50% reduction in overall pain (NRS), proportion of patients with minimal pain (NRS ≤ 2), and high responder rates (PPR ≥ 80%). Data was analyzed for all PSPS patients at the last follow-up, with preliminary analysis of patients who completed 3-year assessments. Results in PSPS type 1 and 2 patients at the last follow-up are also presented. Results: In total, 424 patients (mean age 61.6 ± 13.5 years; 57% female; 61% PSPS type 2) were included. Mean baseline NRS was 8.0 ± 1.4. At the last follow-up (mean 1.6 ± 1.5 years post-implantation), NRS decreased by 5.3 points to 2.7 ± 2.3 (p < 0.0001), 77% of patients achieved ≥50% reduction in pain, 56% reported minimal pain, and 62% were high responders. Similar improvements were observed in the preliminary analysis of 104 PSPS patients who completed the 3-year follow-up, with ≥5-point reduction in the NRS, 77% responder rate, 60% patients with minimal pain, and 70% high responders. The analysis of PSPS type 1 and 2 populations, adjusted for baseline NRS and follow-up durations, showed comparable outcomes. Conclusions: In this global, observational, “as-treated” cohort, favorable real-world outcomes were observed in PSPS patients using FAST-SCS, supporting its use as an effective treatment option in chronic spinal pain management.", "abstract_shown": true, "affiliations": [ "Orthopedic Surgery Department, HCA Florida West Orthopedic Specialists, Pensacola, FL 32514, USA", "Interventional Pain Management Department, Multidisciplinary Pain Management Services, Okemos, MI 48864, USA", "Department of Neurosurgery, Hospital Universitario La Paz, 28046 Madrid, Spain", "Johanniter-Kliniken Hamm, 59063 Hamm, Germany", "Department of Neuro-Spine and Neuromodulation, Poitiers University Hospital, 86021 Poitiers, France", "Department of Anesthesiology and Pain Management, James Cook University Hospital, Middlesbrough TS4 3BW, UK", "Department of Anesthesiology and Pain Management, Hospital de la Ribera, 46600 Valencia, Spain", "Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, 50937 Cologne, Germany", "Department of Anesthesiology and Pain Management, Southmead Hospital, Bristol BS10 5NB, UK", "Department of Anesthesiology and Pain Management, Rijnstate Hospital, 6815 AD Arnhem, The Netherlands", "Department of Stereotactic and Functional Neurosurgery, Heinrich Heine University, 40225 Düsseldorf, Germany", "Interventional Pain Management Department, Florida Pain Clinic, Ocala, FL 34471, USA", "Department of Neurosurgery, Inter Neuro, 10629 Berlin, Germany" ], "article_type": "research article", "arxiv": null, "author_total": 14, "authors": [ { "affs": [ 0 ], "name": "Clark Metzger" }, { "affs": [ 0 ], "name": "Blake Hammond" }, { "affs": [ 1 ], "name": "Richard Ferro", "orcid": "0009-0009-5813-315X" }, { "affs": [ 2 ], "name": "Jose Paz-Solis", "orcid": "0000-0002-9555-3171" }, { "affs": [ 3 ], "name": "Georgios Kyriakopoulos" }, { "affs": [ 4 ], "name": "Philippe Rigoard", "orcid": "0000-0001-9432-5807" }, { "affs": [ 5 ], "name": "Ashish Gulve" }, { "affs": [ 6 ], "name": "Jose Emilio Llopis", "orcid": "0000-0003-2165-6933" }, { "affs": [ 7 ], "name": "Pablo Andrade", "orcid": "0000-0002-2596-7301" }, { "affs": [ 8 ], "name": "Sarah Love-Jones" }, { "affs": [ 9 ], "name": "Jan Willem Kallewaard", "orcid": "0000-0002-7681-1796" }, { "affs": [ 10 ], "name": "Jan Vesper" }, { "affs": [ 11 ], "name": "Stephen Pyles" }, { "affs": [ 12 ], "name": "Simon Bayerl" } ], "bibtex": "https://research.draconitic.com/paper/f2qj0v5wfjmn3.bib", "cited_by": 0, "doi": "10.3390/jcm15197640", "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666453/?tool=EBI", "id": "f2qj0v5wfjmn3", "issns": [ "2077-0383" ], "landing_url": "https://europepmc.org/article/PMC/PMC13666453", "language": "eng", "licence": "CC-BY", "licence_label": "CC BY", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "2703|Pain Management and Treatment" ] ], "openalex": "W7216339653", "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666453/pdf/?tool=EBI", "pmcid": "PMC13666453", "pmid": null, "published": "2026-10-01", "publisher": "MDPI AG", "ris": "https://research.draconitic.com/paper/f2qj0v5wfjmn3.ris", "sources": [ { "first_seen": "2026-10-30T12:17:35Z", "native_id": "PMC:PMC13666453", "source": "europepmc", "url": "https://europepmc.org/article/PMC/PMC13666453" }, { "first_seen": "2026-10-30T12:20:00Z", "native_id": "10.3390/jcm15197640", "source": "crossref", "url": "https://www.mdpi.com/2077-0383/15/19/7640" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2703|Pain Management and Treatment", "subfield": "surgery" } ], "title": "Fast-Acting Subperception Spinal Cord Stimulation for Persistent Spinal Pain Syndromes: Real-World Outcomes for up to 3 Years in an “As-Treated” Cohort from a Global Observational Study", "title_text": "Fast-Acting Subperception Spinal Cord Stimulation for Persistent Spinal Pain Syndromes: Real-World Outcomes for up to 3 Years in an “As-Treated” Cohort from a Global Observational Study", "type": "peer-reviewed", "updated_at": "2026-10-30T12:20:00Z", "url": "https://research.draconitic.com/paper/f2qj0v5wfjmn3", "venue": "Journal of clinical medicine", "versions": [] }