{
  "abstract": "Background: Several lung cancer screening (LCS) programmes have identified a high prevalence of people with new (often pre-bronchodilator) airflow obstruction, but demonstrable translation into confirmed chronic obstructive pulmonary disease (COPD) diagnosis is limited. We evaluated a community-based, one-stop, post-bronchodilator case-finding and initial management pathway following LCS.\n\nMethods: Participants undergoing low-dose computed tomography (LDCT) as part of a LCS programme who reported respiratory symptoms were invited to attend a community-based assessment. The pathway included post-bronchodilator spirometry, clinical review and initial management delivered within a single encounter. The primary outcomes were uptake and new clinical diagnosis of COPD. Secondary outcomes included symptom burden, relationship to CT findings, socioeconomic variation and participant-reported experience.\n\nResults: Of 2860 invitation letters issues, 529 (18.5%) invitees participated; a further 33 participants self-presented. Of 562 participants overall, 486 completed spirometry, including 407 without a prior COPD diagnosis. Of these, 100 (25%) participants received a new clinical diagnosis of COPD, mainly with mild-to-moderate airflow obstruction. Among participants with a COPD Assessment Test (CAT) score ≥10, Medical Research Council (MRC) dyspnoea score ≥2, or clinician-defined respiratory symptoms, 35%, 34%, and 38%, respectively, had airflow obstruction. Moderate-to-severe CT emphysema was highly specific but poorly sensitive for airflow obstruction. We detected no significant difference in new COPD diagnosis across deprivation quintiles. Participant-reported experience was very positive.\n\nConclusion: A community-based, one-stop pathway following LCS can identify clinically meaningful COPD diagnosis in symptomatic individuals. This single encounter approach addresses a key gap in current LCS-linked pathways, maximising opportunities for case finding and supporting accessible, patient-centred diagnostic services.",
  "abstract_shown": true,
  "affiliations": [
    "Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK",
    "NIHR Nottingham Biomedical Research Centre, Nottingham, UK",
    "Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK",
    "Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Amna Burzic",
      "orcid": "0009-0009-1099-820X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Malik Hamrouni",
      "orcid": "0000-0002-5523-5435"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Joanne Porte",
      "orcid": "0000-0001-8856-190X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ayushman Gupta",
      "orcid": "0000-0002-2345-545X"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Rachael L Murray",
      "orcid": "0000-0001-5477-2557"
    },
    {
      "affs": [
        0
      ],
      "name": "Tricia M McKeever",
      "orcid": "0000-0003-0914-0416"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Emma O’Dowd",
      "orcid": "0000-0001-6904-1327"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Charlotte E Bolton",
      "orcid": "0000-0002-9578-2249"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f2tha9wjcap6e.bib",
  "cited_by": 0,
  "doi": "10.2147/copd.s634297",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733389/",
  "id": "f2tha9wjcap6e",
  "issns": [
    "1176-9106",
    "1178-2005"
  ],
  "landing_url": "https://doi.org/10.2147/copd.s634297",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2740|Chronic Obstructive Pulmonary Disease (COPD) Research"
    ]
  ],
  "openalex": "W7225013217",
  "pdf_url": "https://www.dovepress.com/article/download/121649",
  "pmcid": "PMC13733389",
  "pmid": "42985238",
  "published": "2026-10-31",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/f2tha9wjcap6e.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:10Z",
      "native_id": "PMC13733389",
      "source": "pmc",
      "url": "https://doi.org/10.2147/copd.s634297"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Chronic Obstructive Pulmonary Disease (COPD) Research",
      "subfield": "general"
    }
  ],
  "title": "Case Finding for COPD in Nottingham and District (C FIND COPD). A Pilot Study of Uptake, Acceptability and Diagnostic Yield in a One-Stop Assessment Following Lung Cancer Screening",
  "title_text": "Case Finding for COPD in Nottingham and District (C FIND COPD). A Pilot Study of Uptake, Acceptability and Diagnostic Yield in a One-Stop Assessment Following Lung Cancer Screening",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:10Z",
  "url": "https://research.draconitic.com/paper/f2tha9wjcap6e",
  "venue": "International Journal of Chronic Obstructive Pulmonary Disease",
  "versions": []
}