{
  "abstract": "Background: It was recently established that patients who developed venous thromboembolism (VTE) are at increased risk of major adverse cardiovascular events (MACE) than the general population. However, whether the anticoagulation used for VTE influences the risk of MACE remains undescribed.\n\nResearch question: Does the anticoagulant treatment for VTE impact the risk of subsequent MACE?\n\nStudy design and methods: We included patients from a large prospective cohort, who received only one family of anticoagulant treatment after the acute phase of VTE, among which, vitamin K antagonist (VKA), and direct oral anticoagulants (DOAC). MACE included nonfatal acute coronary syndrome, non-fatal stroke, and all-cause death. The secondary outcome, MACE-2, included cardiovascular death instead of all-cause death. Cox proportional and Fine-Gray models served to study the relationship between anticoagulation characteristics and the risk of outcomes.\n\nResults: A total of 3790 patients (47.2% of men, mean age: 60.48 years) were included. 1228 patients (32.4%) were treated for 0 to 3 months (median in overall population: 6 months).\n\nCompared to these patients, those treated for 3 to 12 (HR: 0.64, 95% CI: 0.54 -0.76), or over 12 months (HR: 0.47, 95% CI: 0.39 -0.56) had a significant reduced risk of MACE after adjustment for confounders. Findings were similar for MACE-2 (HR-3-12 months: 0.61, 95% CI: 0.47 -0.79; HR-over 12 months: 0.52, 95% CI: 0.39 -0.68). After adjustment for confounders, there was a reduced risk of MACE (HR: 0.53, 95% CI: 0.39 -0.71) and MACE-2 (HR: 0.48, 95% CI: 0.29 -0.77) in patients treated with DOAC (vs. VKA).\n\nInterpretation: Treatment of VTE for more than 3 months is associated with a reduced risk of MACE, as is treatment with DOAC versus VKA. These findings, which may influence the choice of anticoagulation strategies for VTE, need confirmation by randomized clinical trials.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Steve Raoul Noumegni"
    },
    {
      "name": "Raphael Le Mao"
    },
    {
      "name": "Claire de Moreuil"
    },
    {
      "name": "Clément Hoffmann"
    },
    {
      "name": "Emmanuelle Le Moigne"
    },
    {
      "name": "Cécile Tromeur"
    },
    {
      "name": "Vincent Mansourati"
    },
    {
      "name": "Bahaa Nasr"
    },
    {
      "name": "Jean-Christophe Gentric"
    },
    {
      "name": "Marie Guegan"
    },
    {
      "name": "Elise Poulhazan"
    },
    {
      "name": "Luc Bressollette"
    },
    {
      "name": "Karine Lacut"
    },
    {
      "name": "Romain Didier"
    },
    {
      "name": "Francis Couturaud"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f2xhvg0w6pqsv.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": null,
  "id": "f2xhvg0w6pqsv",
  "issns": [
    "0012-3692",
    "1931-3543"
  ],
  "landing_url": "https://hal.science/hal-05753551v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://hal.science/hal-05753551/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-17",
  "publisher": "American College of Chest Physicians",
  "ris": "https://research.draconitic.com/paper/f2xhvg0w6pqsv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "hal-05753551",
      "source": "hal",
      "url": "https://hal.science/hal-05753551v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Anticoagulation for Venous Thromboembolism: Impact on the Risk of Major Adverse Cardiovascular Events",
  "title_text": "Anticoagulation for Venous Thromboembolism: Impact on the Risk of Major Adverse Cardiovascular Events",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/f2xhvg0w6pqsv",
  "venue": "Chest",
  "versions": []
}